| Gene Symbol |
AASS
|
| Entrez Gene |
10157
|
| Alt Symbol |
LKR/SDH, LKRSDH, LORSDH
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
aminoadipate-semialdehyde synthase
|
| Other Description |
alpha-aminoadipate semialdehyde synthase|alpha-aminoadipic semialdehyde synthase, mitochondrial|aminoadipic semialdehyde synthase|lysine-2-oxoglutarate reductase|lysine-ketoglutarate reductase /saccharopine dehydrogenase
|
| Swissprots |
O95462 Q9UDR5
|
| Accessions |
AAF03526 EAL24343 EAW83564 EAW83565 Q9UDR5 AF229180 AAF44328 AJ007714 CAA07619 AK023446 BAG51195 AK225898 AK294326 BAG57598 BC144246 BC144247 BC156456 AAI56457 BC172503 AAI72503 BM669241 DA995180 XM_011515725 XP_011514027 XM_011515726 XP_011514028 XR_242220 XR_242221 XR_927326 NM_005763 NP_005754
|
| Function |
Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively.
|
| Subcellular Location |
Mitochondrion {ECO:0000250}.
|
| Tissue Specificity |
Expressed in all 16 tissues examined with highest expression in the liver.
|
| Top Pathways |
Lysine degradation
|