| Gene Symbol |
ELOVL2
|
| Entrez Gene |
54898
|
| Alt Symbol |
SSC2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ELOVL fatty acid elongase 2
|
| Other Description |
3-keto acyl-CoA synthase ELOVL2|ELOVL FA elongase 2|elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2|elongation of very long chain fatty acids protein 2|very-long-chain 3-oxoacyl-CoA synthase 2
|
| Swissprots |
Q6P9E1 Q86W94 Q9NXB9
|
| Accessions |
EAW55290 EAW55291 EAW55292 Q9NXB9 AJ420504 AK000341 BAA91096 AL080199 BC050278 AAH50278 BC060809 AAH60809 HQ448547 ADQ33026 XM_011514716 XP_011513018 XM_011514717 XP_011513019 NM_017770 NP_060240
|
| Function |
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n- 6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:12371743, ECO:0000269|PubMed:20937905}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255}.
|
| Tissue Specificity |
Liver and testis. {ECO:0000269|PubMed:20937905}.
|
| Top Pathways |
Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism
|