| Gene Symbol | ELOVL2 |
|---|---|
| Entrez Gene | 54898 |
| Alt Symbol | SSC2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ELOVL fatty acid elongase 2 |
| Other Description | 3-keto acyl-CoA synthase ELOVL2|ELOVL FA elongase 2|elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2|elongation of very long chain fatty acids protein 2|very-long-chain 3-oxoacyl-CoA synthase 2 |
| Swissprots | Q6P9E1 Q86W94 Q9NXB9 |
| Accessions | EAW55290 EAW55291 EAW55292 Q9NXB9 AJ420504 AK000341 BAA91096 AL080199 BC050278 AAH50278 BC060809 AAH60809 HQ448547 ADQ33026 XM_011514716 XP_011513018 XM_011514717 XP_011513019 NM_017770 NP_060240 |
| Function | Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n- 6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:12371743, ECO:0000269|PubMed:20937905}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255}. |
| Tissue Specificity | Liver and testis. {ECO:0000269|PubMed:20937905}. |
| Top Pathways | Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism |
ELOVL2 CRISPR/Cas9 KO Plasmid (h) - sc-404998 from Santa Cruz Biotechnology
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ELOVL2 HDR Plasmid (h) - sc-404998-HDR from Santa Cruz Biotechnology
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ELOVL2 Double Nickase Plasmid (h) - sc-404998-NIC from Santa Cruz Biotechnology
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ELOVL2 Double Nickase Plasmid (h2) - sc-404998-NIC-2 from Santa Cruz Biotechnology
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ELOVL2 CRISPR Activation Plasmid (h) - sc-404998-ACT from Santa Cruz Biotechnology
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ELOVL2 CRISPR Activation Plasmid (h2) - sc-404998-ACT-2 from Santa Cruz Biotechnology
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ELOVL2 Lentiviral Activation Particles (h) - sc-404998-LAC from Santa Cruz Biotechnology
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ELOVL2 Lentiviral Activation Particles (h2) - sc-404998-LAC-2 from Santa Cruz Biotechnology
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ELOVL2 siRNA (h) - sc-62265 from Santa Cruz Biotechnology
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ELOVL2 shRNA Plasmid (h) - sc-62265-SH from Santa Cruz Biotechnology
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ELOVL2 shRNA (h) Lentiviral Particles - sc-62265-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU033101 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7821 from Sigma-Aldrich
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ELOVL2 siRNA (Human) - CRJ0307 from Cohesion Biosciences
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ELOVL2 - MBS8204886 from MyBioSource
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shRNA set against Human ELOVL2 (NM_017770.3) - SHH285257 from Creative biogene
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shRNA set against Human ELOVL2(NM_017770.3) - SHH031691 from Creative biogene
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Human ELOVL2 siRNA - orb270808 from Biorbyt
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ELOVL2 shRNA Plasmid (Human) - CHJ0307 from Cohesion Biosciences
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ELOVL2 miRNA 3'UTR clone - MiUTR1H-03206 from Creative biogene
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