| Gene Symbol | TNIP3 |
|---|---|
| Entrez Gene | 79931 |
| Alt Symbol | ABIN-3, LIND |
| Species | Human |
| Gene Type | protein-coding |
| Description | TNFAIP3 interacting protein 3 |
| Other Description | A20-binding inhibitor of NF-kappa-B activation 3|ABIN-3 beta|Listeria induced|TNFAIP3-interacting protein 3|TNFAIP3-interacting protein 3 beta|TNIP3 beta|listeria-induced gene protein |
| Swissprots | B4DVF5 B4E023 Q96PQ3 A1A574 Q96KP6 Q9H780 A8K2Z4 |
| Accessions | EAX05263 EAX05264 EAX05265 Q96KP6 AF277289 AAL02151 AJ320534 CAC85929 AK024815 BAB15018 AK290409 BAF83098 AK301058 BAG62667 AK303192 BAG64285 BC128408 AAI28409 BP335455 CD367219 DC389224 EF585496 ABQ40006 XM_011532256 XP_011530558 XM_011532257 XP_011530559 XM_011532258 XP_011530560 XM_011532259 XP_011530561 NM_001128843 NP_001122315 NM_001244764 NP_001231693 NM_024873 NP_079149 |
| Function | Binds to zinc finger protein TNFAIP3 and inhibits NF- kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13- acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding. {ECO:0000269|PubMed:17088249}. |
| Tissue Specificity | Highly expressed in lung, lymph node, thymus and fetal liver. Expressed at lower levels in bone marrow, brain, kidney, spleen, leukocytes and tonsils. Could be detected in heart, salivary gland, adrenal gland, pancreas, ovary and fetal brain. High levels detected in liver, colon, small intestine, muscle, stomach, testis, placenta, thyroid, uterus, prostate, skin and PBL. {ECO:0000269|PubMed:11345586, ECO:0000269|PubMed:17088249}. |