ERCC8

Gene Symbol	ERCC8
Entrez Gene	1161
Alt Symbol	CKN1, CSA, UVSS2
Species	Human
Gene Type	protein-coding
Description	excision repair cross-complementation group 8
Other Description	Cockayne syndrome WD-repeat protein CSA\|DNA excision repair protein ERCC-8\|cockayne syndrome WD repeat protein CSA\|excision repair cross-complementing rodent repair deficiency, complementation group 8
Swissprots	Q13216 Q6FHX5 Q96GB9 B2RB64
Accessions	AAO21128 EAW55003 EAW55004 EAW55005 Q13216 AK022657 AK056931 BAG51829 AK226129 AK290726 BAF83415 AK294856 BAG57960 AK304610 BAG65395 AK314511 BAG37111 AL691658 BC009793 AAH09793 BC093802 BC112227 BT020021 AAV38824 CR536563 CAG38800 DA169067 U28413 AAA82605 NM_000082 NP_000073 NM_001007233 NP_001007234 NM_001007234 NP_001007235 NM_001290285 NP_001277214
Function	Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription- coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. {ECO:0000269\|PubMed:16751180, ECO:0000269\|PubMed:16916636, ECO:0000269\|PubMed:16964240}.
Subcellular Location	Nucleus {ECO:0000305}.
Top Pathways	Ubiquitin mediated proteolysis, Nucleotide excision repair

CSA (D-2) - sc-376981 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

CSA (D-2): sc-376981. Western blot analysis of CSA expression in Jurkat nuclear extract.

CSA (C-18) - sc-10998 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CSA (C-18): sc-10998. Immunofluorescence staining of methanol-fixed JAR cells showing nuclear localization.

CSA (H-266) - sc-25369 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

CSA (W-16) - sc-10997 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CSA (235C3a) - sc-81560 from Santa Cruz Biotechnology

Prices	$295.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

CSA (235C3a): sc-81560 Western Blot analysis of human recombinant CSA fusion protein.

Anti-ERCC8 antibody - ab107290 from Abcam

Prices	$376.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ERCC8 antibody (ab107290) at 1/100 dilution + Mouse spleen tissue lysate at 35 µg

Anti-ERCC8 antibody - ab86114 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ERCC8 antibody (ab86114) at 1 µg/ml (5% skim milk/ PBS buffer) + HepG2 cell lyate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-ERCC8 antibody - ab54639 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Western blot against tagged recombinant protein immunogen using ab54639 ERCC8 antibody at 1ug/ml.

Anti-ERCC8 antibody [235C3a] - ab58882 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	235C3a

Anti-ERCC8 antibody [235C3a] (ab58882) + immunizing recombinant fragment

Anti-ERCC8 antibody [EPR9237] - ab137033 from Abcam

Prices	$379.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR9237

All lanes : Anti-ERCC8 antibody [EPR9237] (ab137033) at 1/1000 dilutionLane 1 : Hela cell lysateLane 2 : Molt 4 cell lysateLane 3 : 293T cell lysateLane 4 : HepG2 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP conjugated Goat anti Rabbit IgG at 1/2000 dilution

Anti-CSA / ERCC8 Antibody (C-Terminus) - LS-C345795 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Western blot of ERCC8 Antibody with human Jurkat Whole Cell lysate.

Anti-CSA / ERCC8 Antibody (clone 235C3a) - LS-C342635 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	235C3a

Western blot analysis of immunized recombinant protein, using anti-ERCC8 monoclonal antibody.

Anti-CSA / ERCC8 Antibody IHC-plus™ - LS-B4076 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-ERCC8 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4076 concentration 10 ug/ml.

Anti-CSA / ERCC8 Antibody - LS-C65572 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal

Anti-CSA / ERCC8 Antibody (aa37-86) - LS-C30134 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CSA / ERCC8 Antibody (aa72-121) - LS-C102730 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

ERCC8 antibody LS-C102730 Western blot of Placenta lysate.

Anti-CSA / ERCC8 Antibody (C-Terminus) - LS-C102802 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

ERCC8 antibody LS-C102802 Western blot of HepG2 cell lysate.

Anti-CSA / ERCC8 Antibody (clone 235C3a) - LS-C184601 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	235C3a

Anti-CSA / ERCC8 Antibody (aa210-238, AP) - LS-C208891 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CSA / ERCC8 Antibody (aa216-265) - LS-C112132 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

ERCC8 antibody LS-C112132 Western blot of HeLa lysate.

Anti-CSA / ERCC8 Antibody (C-Terminus) - LS-C116795 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

ERCC8 antibody LS-C116795 Western blot of Jurkat lysate.

Anti-CSA / ERCC8 Antibody - LS-C109290 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Immunofluorescence of paraformaldehyde-fixed HeLa, using ERCC8 antibody at 1:200 dilution.

Anti-CSA / ERCC8 Antibody (aa210-238, APC) - LS-C208892 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CSA / ERCC8 Antibody (aa210-238, Biotin) - LS-C208893 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CSA / ERCC8 Antibody (aa210-238, FITC) - LS-C208894 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

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