ERCC8

Gene Symbol	ERCC8
Entrez Gene	1161
Alt Symbol	CKN1, CSA, UVSS2
Species	Human
Gene Type	protein-coding
Description	excision repair cross-complementation group 8
Other Description	Cockayne syndrome WD-repeat protein CSA|DNA excision repair protein ERCC-8|cockayne syndrome WD repeat protein CSA|excision repair cross-complementing rodent repair deficiency, complementation group 8
Swissprots	Q13216 Q6FHX5 Q96GB9 B2RB64
Accessions	AAO21128 EAW55003 EAW55004 EAW55005 Q13216 AK022657 AK056931 BAG51829 AK226129 AK290726 BAF83415 AK294856 BAG57960 AK304610 BAG65395 AK314511 BAG37111 AL691658 BC009793 AAH09793 BC093802 BC112227 BT020021 AAV38824 CR536563 CAG38800 DA169067 U28413 AAA82605 NM_000082 NP_000073 NM_001007233 NP_001007234 NM_001007234 NP_001007235 NM_001290285 NP_001277214
Function	Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription- coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. {ECO:0000269|PubMed:16751180, ECO:0000269|PubMed:16916636, ECO:0000269|PubMed:16964240}.
Subcellular Location	Nucleus {ECO:0000305}.
Top Pathways	Ubiquitin mediated proteolysis, Nucleotide excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ERCC8 full length protein - ab114805 from Abcam Category Protein Source Wheat germ Species Human

Human ERCC8 full length protein - ab152282 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human ERCC8 Protein - H00001161-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ERCC8-Antibody-Center-Blocking-peptide - BP10955c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ERCC8 Blocking Peptide - 33R-3030 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ERCC8 - H00001161-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ERCC8 - H00001161-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ERCC8 - H00001161-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

ERCC8 - H00001161-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ERCC8 - H00001161-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ERCC8 fusion protein - Ag9096 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

ERCC8 fusion protein - ag8734 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human ERCC8 - ERCC8-26850TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human ERCC8, His-tagged - ERCC8-12527H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human DNA excision repair protein ERCC-8(ERCC8) - CSB-YP621655HU CSB-EP621655HU CSB-BP621655HU CSB-MP621655HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human ERCC8 Protein - H00001161-P01 from Novus Biologicals Category Protein Prices $305.00, $445.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ERCC8 Protein - abx163794 from Abbexa Category Protein Species Human

ERCC8 (full length, N-term HIS tag, transcript variant 3) - TP760049 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

ERCC8 Peptide, Human - M34GP05041H from Creative Peptides Category Peptide Source Synthetic. Species Human

ERCC8 Recombinant Protein Antigen - NBP2-58562PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DNA excision repair protein ERCC-8 (ERCC8), Recombinant Protein - MBS1313369 from MyBioSource Category Protein Prices $1,170.00, $1,170.00, $1,395.00, $1,395.00, $1,870.00, $1,870.00, $2,335.00, $2,335.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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