ERCC8

Gene Symbol	ERCC8
Entrez Gene	1161
Alt Symbol	CKN1, CSA, UVSS2
Species	Human
Gene Type	protein-coding
Description	excision repair cross-complementation group 8
Other Description	Cockayne syndrome WD-repeat protein CSA|DNA excision repair protein ERCC-8|cockayne syndrome WD repeat protein CSA|excision repair cross-complementing rodent repair deficiency, complementation group 8
Swissprots	Q13216 Q6FHX5 Q96GB9 B2RB64
Accessions	AAO21128 EAW55003 EAW55004 EAW55005 Q13216 AK022657 AK056931 BAG51829 AK226129 AK290726 BAF83415 AK294856 BAG57960 AK304610 BAG65395 AK314511 BAG37111 AL691658 BC009793 AAH09793 BC093802 BC112227 BT020021 AAV38824 CR536563 CAG38800 DA169067 U28413 AAA82605 NM_000082 NP_000073 NM_001007233 NP_001007234 NM_001007234 NP_001007235 NM_001290285 NP_001277214
Function	Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription- coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. {ECO:0000269|PubMed:16751180, ECO:0000269|PubMed:16916636, ECO:0000269|PubMed:16964240}.
Subcellular Location	Nucleus {ECO:0000305}.
Top Pathways	Ubiquitin mediated proteolysis, Nucleotide excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CSA CRISPR/Cas9 KO Plasmid (h) - sc-403428 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CSA HDR Plasmid (h) - sc-403428-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CSA Double Nickase Plasmid (h) - sc-403428-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CSA Double Nickase Plasmid (h2) - sc-403428-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CSA CRISPR Activation Plasmid (h) - sc-403428-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CSA CRISPR Activation Plasmid (h2) - sc-403428-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CSA Lentiviral Activation Particles (h) - sc-403428-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CSA Lentiviral Activation Particles (h2) - sc-403428-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CSA siRNA (h) - sc-37792 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CSA shRNA Plasmid (h) - sc-37792-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CSA shRNA (h) Lentiviral Particles - sc-37792-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ERCC8 RNAi - H00001161-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

ERCC8 RNAi - H00001161-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

ERCC8 RNAi - H00001161-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU109451 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7955 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7955 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06373 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr06373

ERCC8 siRNA (Human) - CRH0833 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ERCC8 - MBS8213904 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human ERCC8 (NM_000082.3) - SHH286961 from Creative biogene Category siRNA Species Reactivities Human

Human ERCC8 siRNA - orb261335 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ERCC8 shRNA Plasmid (Human) - CHH0833 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

ERCC8 miRNA 3'UTR clone - MiUTR3H-10596 from Creative biogene Species Reactivities Human

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