ERCC8

Gene Symbol	ERCC8
Entrez Gene	1161
Alt Symbol	CKN1, CSA, UVSS2
Species	Human
Gene Type	protein-coding
Description	excision repair cross-complementation group 8
Other Description	Cockayne syndrome WD-repeat protein CSA|DNA excision repair protein ERCC-8|cockayne syndrome WD repeat protein CSA|excision repair cross-complementing rodent repair deficiency, complementation group 8
Swissprots	Q13216 Q6FHX5 Q96GB9 B2RB64
Accessions	AAO21128 EAW55003 EAW55004 EAW55005 Q13216 AK022657 AK056931 BAG51829 AK226129 AK290726 BAF83415 AK294856 BAG57960 AK304610 BAG65395 AK314511 BAG37111 AL691658 BC009793 AAH09793 BC093802 BC112227 BT020021 AAV38824 CR536563 CAG38800 DA169067 U28413 AAA82605 NM_000082 NP_000073 NM_001007233 NP_001007234 NM_001007234 NP_001007235 NM_001290285 NP_001277214
Function	Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription- coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. {ECO:0000269|PubMed:16751180, ECO:0000269|PubMed:16916636, ECO:0000269|PubMed:16964240}.
Subcellular Location	Nucleus {ECO:0000305}.
Top Pathways	Ubiquitin mediated proteolysis, Nucleotide excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ERCC8-Over-expression-Lysate - LY12423a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

ERCC8 293T Cell Transient Overexpression Lysate(Denatured) - H00001161-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

ERCC8 293T Cell Transient Overexpression Lysate(Denatured) - H00001161-T02 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

ERCC8 overexpression lysate - LY423459 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

ERCC8 overexpression lysate - LY424939 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

ERCC8 overexpression lysate - LY424984 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

ERCC8 293 Cell Lysate - 409947 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

ERCC8 Overexpression Lysate (Denatured) - H00001161-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

ERCC8 Overexpression Lysate (Native) - NBL1-10324 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

ERCC8 Over-expression Lysate Product - GWB-577620 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

ERCC8 Overexpression Lysate (Denatured) - H00001161-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human ERCC8 Knockdown Stable Cell Line - CSC-DC005041 from Creative biogene Category Cell Line Species Human

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