ASPN

Gene Symbol	ASPN
Entrez Gene	54829
Alt Symbol	OS3, PLAP-1, PLAP1, SLRR1C
Species	Human
Gene Type	protein-coding
Description	asporin
Other Description	asporin (LRR class 1)|asporin proteoglycan|periodontal ligament associated protein 1|small leucine-rich protein 1C
Swissprots	Q96K79 Q9BXN1 Q5TBF3 Q96LD0 Q9NXP3
Accessions	CCO13682 EAW62822 EAW62823 Q9BXN1 AF316824 AAK35161 AI741321 AK000136 BAA90967 AK027359 BAB55060 AK172737 AK304501 BAG65309 AK308107 AY029191 AAK31800 AY358329 AAQ88695 BC022059 AAH22059 BC063114 AAH63114 BP292032 CD110559 NM_001193335 NP_001180264 NM_017680 NP_060150
Function	Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF- beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity. {ECO:0000250, ECO:0000269|PubMed:17827158, ECO:0000269|PubMed:19589127}.
Subcellular Location	Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17827158}.
Tissue Specificity	Higher levels in osteoarthritic articular cartilage, aorta, uterus. Moderate expression in small intestine, heart, liver, bladder, ovary, stomach, and in the adrenal, thyroid, and mammary glands. Low expression in trachea, bone marrow, and lung. Colocalizes with TGFB1 in chondrocytes within osteoarthritic (OA) lesions of articular cartilage. {ECO:0000269|PubMed:17827158}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ASPN / Asporin ELISA Kit (Sandwich ELISA) - LS-F6536 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.126 ng/ml Range 0.313-20 ng/ml

Mouse ASPN / Asporin ELISA Kit (Sandwich ELISA) - LS-F7795 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 0.313-20 ng/ml

Human Asporin ELISA Kit - abx150758 from Abbexa Category ELISA Kit Sensitivity 0.126 ng/ml Range 0.313 ng/ml - 20 ng/ml

Asporin, ASPN, Human, ELISA Kit - E-EL-H0515 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Asporin (ASPN), Human, ELISA Kit - CSB-EL002230HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 8.59 pg/ml Range 34.37 pg/ml-2200 pg/ml

Asporin (ASPN), Human, ELISA Kit - SEC321Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.118ng/mL Range 0.312-20ng/mL

Asporin, ASPN, Human, ELISA Kit - E1043h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Asporin, Human, ELISA Kit - E01A0330 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1 ng/mL Range 1.0-25 ng/mL

Asporin, ASPN, Rabbit, ELISA Kit - E-EL-RB0918 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Asporin, ASPN, Chicken, ELISA Kit - E-EL-Ch1752 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Asporin, ASPN, Porcine, ELISA Kit - E-EL-P0343 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Asporin, ASPN, Sheep, ELISA Kit - E-EL-S0796 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Asporin, ASPN, Guinea Pig, ELISA Kit - E-EL-GP0209 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Asporin, ASPN, Monkey, ELISA Kit - E-EL-MK0326 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human ASPN ELISA Kit - HA0337 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine ASPN ELISA Kit - AA0337 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

ASPN, ELISA Kit - MBS2502153 from MyBioSource Category ELISA Kit Prices $490.00, $585.00, $2,475.00, $4,360.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

ASPN, ELISA Kit - MBS2507283 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

ASPN, ELISA Kit - MBS2508199 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

ASPN, ELISA Kit - MBS2512337 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

ASPN, ELISA Kit - MBS2507751 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313--20ng/mL

ASPN, ELISA Kit - MBS2509291 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

ASPN, ELISA Kit - MBS2512383 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 75pg/mL Range 125-8000pg/mL

Asporin, ELISA Kit - MBS041472 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Asporin, ELISA Kit - MBS043530 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml. Range 0.625 ng/ml - 20 ng/ml.

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