ASPN

Gene Symbol ASPN
Entrez Gene 54829
Alt Symbol OS3, PLAP-1, PLAP1, SLRR1C
Species Human
Gene Type protein-coding
Description asporin
Other Description asporin (LRR class 1)|asporin proteoglycan|periodontal ligament associated protein 1|small leucine-rich protein 1C
Swissprots Q96K79 Q9BXN1 Q5TBF3 Q96LD0 Q9NXP3
Accessions CCO13682 EAW62822 EAW62823 Q9BXN1 AF316824 AAK35161 AI741321 AK000136 BAA90967 AK027359 BAB55060 AK172737 AK304501 BAG65309 AK308107 AY029191 AAK31800 AY358329 AAQ88695 BC022059 AAH22059 BC063114 AAH63114 BP292032 CD110559 NM_001193335 NP_001180264 NM_017680 NP_060150
Function Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF- beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity. {ECO:0000250, ECO:0000269|PubMed:17827158, ECO:0000269|PubMed:19589127}.
Subcellular Location Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17827158}.
Tissue Specificity Higher levels in osteoarthritic articular cartilage, aorta, uterus. Moderate expression in small intestine, heart, liver, bladder, ovary, stomach, and in the adrenal, thyroid, and mammary glands. Low expression in trachea, bone marrow, and lung. Colocalizes with TGFB1 in chondrocytes within osteoarthritic (OA) lesions of articular cartilage. {ECO:0000269|PubMed:17827158}.

Asporin (E-15) - sc-70118 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Asporin (H-44) - sc-366130 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Asporin (I-14) - sc-70119 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Asporin (I-14): sc-70119. Western blot analysis of Asporin expression in human uterus tissue extract.

Anti-Asporin antibody - ab58741 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Asporin antibody (ab58741) at 2.5 µg/ml + HepG2 cell lysate at 10 µg with skim milk in PBS buffer at 5 %SecondaryHRP conjugated anti-Rabbit IgG at 1: 50,000 - 100,000

Anti-Asporin antibody - ab31303 from Abcam

Prices $394.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-Asporin antibody (ab31303) at 0.3 µg/ml + Human Bone Marrow lysate (35µg protein in RIPA buffer)

Anti-Asporin antibody - ab154404 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Asporin antibody (ab154404) at 1/1000 dilutionLane 1 : A549 whole cell lysate/extractLane 2 : H1299 whole cell lysate/extractLane 3 : HCT116 whole cell lysate/extractLysates/proteins at 30 µg per lane.

Anti-Asporin antibody - ab75317 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Asporin antibody - ab201208 from Abcam

Prices $359.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical staining of Human fetal muscle labeling Asporin using ab201208 at 1/100 dilution.

Anti-ASPN / Asporin Antibody (C-Terminus) - LS-C144892 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ASPN / Asporin Antibody (C-Terminus) - LS-C153382 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ASPN / Asporin Antibody - LS-C306411 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-ASPN / Asporin Antibody - LS-C309538 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ASPN / Asporin Antibody (Internal) - LS-C54549 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody staining of ATDC5 cells (Panels A and C) and DAPI (panels B and D).

Anti-ASPN / Asporin Antibody (aa250-299) - LS-C31930 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ASPN / Asporin antibody LS-C31930 IHC of formalin-fixed, paraffin-embedded human Muscle. Positive label: Skeletal muscle cells indicated with arrows. Antibody concentration 4-8 ug/ml. Magnification 400X.

Anti-ASPN / Asporin Antibody (Internal) - LS-C99335 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma with ASPN Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Asporin Antibody - NB100-1514 from Novus Biologicals

Prices $99.00, $329.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal

Asporin Antibody - NBP2-30071 from Novus Biologicals

Prices $299.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Asporin Antibody [NBP2-30071] - Western blot analysis of ASPN antibody (Center) (NBP2-30071) in HL60 cell line lysates(35ug/lane). ASPN (arrow) was detected using the purified Pab.

Asporin Antibody - NBP2-15492 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Asporin Antibody [NBP2-15492] - Sample (30 ug of whole cell lysate) A: HCT116 10% SDS PAGE gel, diluted at 1:1000.

Asporin Antibody - H00054829-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Asporin Antibody [H00054829-D01P] - Analysis of ASPN expression in mouse testis.

Asporin Antibody - H00054829-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Asporin Antibody - NBP1-58061 from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Asporin Antibody [NBP1-58061] - Sample Tissue: HepG2, Lane A: Primary Antibody, Lane B: Primary Antibody + Blocking Peptide, Primary Antibody Concentration: 2.5ug/mL, Peptide Concentration: 2.0ug/mL, Lysate Quantity: 25ug/lane, Gel Concentration: 12%

Anti-ASPORIN/ASPN antibody produced in goat - SAB2500127 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>IImmunofluorescence</B><BR/>Anti-Asporin / ASPN: <B>Cat. No. SAB2500127</B>: staining of ATDC5 cells (Panels A and C) and DAPI (panels B and D). Data gratefully received from Dr. Shiro Ikegawa, SNP Research Center, RIKEN, Japan.

Anti-ASPN antibody produced in rabbit - HPA024230 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ASPN: <B>Cat. No. HPA024230</B>: Immunohistochemical staining of human stomach shows strong nuclear positivity in glandular cells.

Anti-ASPN (AB3) antibody produced in rabbit - AV42487 from Sigma-Aldrich

Prices $267.50, $267.50
Sizes 100 µg, 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ASPN (ab3): <B>Cat. No. AV42487</B>: Immunohistochemistry of ASPN in Human Muscle tissue with ASPN antibody at 4-8 μg/mL.

Anti-ASPN antibody produced in rabbit - SAB1411014 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-ASPN: <B>Cat. No. SAB1411014</B>: Antibody concentration: 1-5 μg/mL. Specific band of ~43.4 kDa using HeLa lysate.
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