| Gene Symbol |
ASPN
|
| Entrez Gene |
54829
|
| Alt Symbol |
OS3, PLAP-1, PLAP1, SLRR1C
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
asporin
|
| Other Description |
asporin (LRR class 1)|asporin proteoglycan|periodontal ligament associated protein 1|small leucine-rich protein 1C
|
| Swissprots |
Q96K79 Q9BXN1 Q5TBF3 Q96LD0 Q9NXP3
|
| Accessions |
CCO13682 EAW62822 EAW62823 Q9BXN1 AF316824 AAK35161 AI741321 AK000136 BAA90967 AK027359 BAB55060 AK172737 AK304501 BAG65309 AK308107 AY029191 AAK31800 AY358329 AAQ88695 BC022059 AAH22059 BC063114 AAH63114 BP292032 CD110559 NM_001193335 NP_001180264 NM_017680 NP_060150
|
| Function |
Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF- beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity. {ECO:0000250, ECO:0000269|PubMed:17827158, ECO:0000269|PubMed:19589127}.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17827158}.
|
| Tissue Specificity |
Higher levels in osteoarthritic articular cartilage, aorta, uterus. Moderate expression in small intestine, heart, liver, bladder, ovary, stomach, and in the adrenal, thyroid, and mammary glands. Low expression in trachea, bone marrow, and lung. Colocalizes with TGFB1 in chondrocytes within osteoarthritic (OA) lesions of articular cartilage. {ECO:0000269|PubMed:17827158}.
|