ASPN

Gene Symbol	ASPN
Entrez Gene	54829
Alt Symbol	OS3, PLAP-1, PLAP1, SLRR1C
Species	Human
Gene Type	protein-coding
Description	asporin
Other Description	asporin (LRR class 1)|asporin proteoglycan|periodontal ligament associated protein 1|small leucine-rich protein 1C
Swissprots	Q96K79 Q9BXN1 Q5TBF3 Q96LD0 Q9NXP3
Accessions	CCO13682 EAW62822 EAW62823 Q9BXN1 AF316824 AAK35161 AI741321 AK000136 BAA90967 AK027359 BAB55060 AK172737 AK304501 BAG65309 AK308107 AY029191 AAK31800 AY358329 AAQ88695 BC022059 AAH22059 BC063114 AAH63114 BP292032 CD110559 NM_001193335 NP_001180264 NM_017680 NP_060150
Function	Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF- beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity. {ECO:0000250, ECO:0000269|PubMed:17827158, ECO:0000269|PubMed:19589127}.
Subcellular Location	Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17827158}.
Tissue Specificity	Higher levels in osteoarthritic articular cartilage, aorta, uterus. Moderate expression in small intestine, heart, liver, bladder, ovary, stomach, and in the adrenal, thyroid, and mammary glands. Low expression in trachea, bone marrow, and lung. Colocalizes with TGFB1 in chondrocytes within osteoarthritic (OA) lesions of articular cartilage. {ECO:0000269|PubMed:17827158}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Asporin full length protein - ab132382 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human Asporin peptide - ab134013 from Abcam Category Peptide Prices $176.00 Sizes 100 µg Species Human

ASPN / Asporin Antibody Blocking Peptide - LS-E8325 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ASPN / Asporin Antibody Blocking Peptide - LS-E25840 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Asporin Protein - H00054829-P01 from Novus Biologicals Category Protein Prices $319.00, $369.00, $529.00 Sizes 2 µg, 10 µg, 25 µg Source Wheat Germ Species Human

ASPN-Antibody-Center-Blocking-Peptide - BP6604c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Asporin blocking peptide - GTX89589-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Asporin Blocking Peptide - 33R-6743 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Asporin Peptide - AC21-0672-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Asporin - H00054829-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Asporin - H00054829-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ASPN Peptide - 42-732P from ProSci Category Peptide Species Human, Mouse

Recombinant Asporin (ASPN) - RPC321Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Asporin (ASPN) - RPC321Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Asporin (ASPN) - RPC321Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Alkaline Phosphatase, Placental (ALPP) - RPB219Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Asporin (ASPN) - RPC321Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Asporin(ASPN) - CSB-YP002230HU CSB-EP002230HU CSB-BP002230HU CSB-MP002230HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Asporin, Recombinant Protein - MBS2031604 from MyBioSource Category Protein Prices $245.00, $450.00, $650.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

Asporin (ASPN) , Recombinant Protein - MBS1292257 from MyBioSource Category Protein Prices $1,760.00, $1,760.00, $2,225.00, $2,225.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Asporin/ASPN, Peptide - MBS425799 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat

ASPN Peptide, Human - M34GP01059H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human Asporin(ASPN) - AP74450 from Signalway Antibody Category Protein Prices $155.00, $390.00, $665.00, $1,090.00, $1,835.00, $2,915.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

ASPN Recombinant Protein (Human) (OPCA04221) - OPCA04221 from Aviva Systems Biology Category Protein Species Human

Recombinant Human Asporin (ASPN) - RPC20946 from Biomatik Category Protein Prices $276.00, $505.00, $2,491.00 Sizes 50 µg, 100 µg, 1 mg Source E.coli Species Human

Search more