| Gene Symbol |
PIAS4
|
| Entrez Gene |
51588
|
| Alt Symbol |
PIAS-gamma, PIASY, Piasg, ZMIZ6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein inhibitor of activated STAT, 4
|
| Other Description |
E3 SUMO-protein ligase PIAS4|protein inhibitor of activated STAT protein 4|protein inhibitor of activated STAT protein PIASy|protein inhibitor of activated STAT protein gamma|zinc finger, MIZ-type containing 6
|
| Swissprots |
Q9UN16 O75926 Q96G19 Q8N2W9
|
| Accessions |
EAW69273 Q8N2W9 AA758531 AF077952 AAC36703 AF164437 AAD45155 AK022481 BAG51076 AK222726 BAD96446 AK315530 BC004389 AAH04389 BC010047 AAH10047 BC029874 AAH29874 BC066895 AAH66895 DQ892419 ABM83345 DQ895633 ABM86559 HY027695 XM_011528060 XP_011526362 NM_016149 NM_015897 NP_056981
|
| Function |
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. {ECO:0000269|PubMed:12511558, ECO:0000269|PubMed:12631292, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:15831457, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:22508508}.
|
| Subcellular Location |
Nucleus, PML body {ECO:0000269|PubMed:11248056, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:15831457}. Note=Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies.
|
| Tissue Specificity |
Highly expressed in testis and, at lower levels, in spleen, prostate, ovary, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:11439351}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Jak-STAT signaling pathway
|