PIAS4

Gene Symbol	PIAS4
Entrez Gene	51588
Alt Symbol	PIAS-gamma, PIASY, Piasg, ZMIZ6
Species	Human
Gene Type	protein-coding
Description	protein inhibitor of activated STAT, 4
Other Description	E3 SUMO-protein ligase PIAS4|protein inhibitor of activated STAT protein 4|protein inhibitor of activated STAT protein PIASy|protein inhibitor of activated STAT protein gamma|zinc finger, MIZ-type containing 6
Swissprots	Q9UN16 O75926 Q96G19 Q8N2W9
Accessions	EAW69273 Q8N2W9 AA758531 AF077952 AAC36703 AF164437 AAD45155 AK022481 BAG51076 AK222726 BAD96446 AK315530 BC004389 AAH04389 BC010047 AAH10047 BC029874 AAH29874 BC066895 AAH66895 DQ892419 ABM83345 DQ895633 ABM86559 HY027695 XM_011528060 XP_011526362 NM_016149 NM_015897 NP_056981
Function	Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. {ECO:0000269|PubMed:12511558, ECO:0000269|PubMed:12631292, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:15831457, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:22508508}.
Subcellular Location	Nucleus, PML body {ECO:0000269|PubMed:11248056, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:15831457}. Note=Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies.
Tissue Specificity	Highly expressed in testis and, at lower levels, in spleen, prostate, ovary, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:11439351}.
Top Pathways	Ubiquitin mediated proteolysis, Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human E3 SUMO-protein ligase PIAS4 full length protein - ab153357 from Abcam Category Protein Source Wheat germ Species Human

PIAS4 / PIASY Antibody Blocking Peptide - LS-E1720 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIAS4 / PIASY Antibody Blocking Peptide - LS-E1727 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIAS4 / PIASY Antibody Blocking Peptide - LS-E2886 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIAS4 / PIASY Antibody Blocking Peptide - LS-E30924 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PIAS4 / PIASY Antibody Blocking Peptide - LS-E11627 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PIASy Protein - H00051588-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

PIASy Peptide - NBP1-77161PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

PIASy Peptide - P0316 from Novus Biologicals Category Peptide Species Human

PIASy Peptide - P0315 from Novus Biologicals Category Peptide Species Human

PIASy1-Antibody-C-term-Blocking-Peptide - BP1250a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIASy-Antibody-N-term-Blocking-peptide - BP1249a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIAS4-Antibody-N-term-Blocking-peptide - BP14013a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIAS4 - H00051588-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

PIAS4 control peptide - AP26205CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

PIAS4 Peptide - 5747P from ProSci Category Peptide Species Human

PIAS4 fusion protein - ag5498 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

PIAS4 fusion protein - Ag13316 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

PIAS4 fusion protein - Ag13329 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PIAS4 Blocking Peptide - CBP4152 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Bovine

PIASy (D488) Peptide - BS1468P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human E3 SUMO-protein ligase PIAS4(PIAS4) - CSB-YP822692HU CSB-EP822692HU CSB-BP822692HU CSB-MP822692HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PIAS4 Protein - abx164166 from Abbexa Category Protein Species Human, Mouse, Rat

PIAS4 - TP306748 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PIAS4 Blocking Peptide - abx162645 from Abbexa Category Peptide Species Human, Bovine

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