PIAS4

Gene Symbol PIAS4
Entrez Gene 51588
Alt Symbol PIAS-gamma, PIASY, Piasg, ZMIZ6
Species Human
Gene Type protein-coding
Description protein inhibitor of activated STAT, 4
Other Description E3 SUMO-protein ligase PIAS4|protein inhibitor of activated STAT protein 4|protein inhibitor of activated STAT protein PIASy|protein inhibitor of activated STAT protein gamma|zinc finger, MIZ-type containing 6
Swissprots Q9UN16 O75926 Q96G19 Q8N2W9
Accessions EAW69273 Q8N2W9 AA758531 AF077952 AAC36703 AF164437 AAD45155 AK022481 BAG51076 AK222726 BAD96446 AK315530 BC004389 AAH04389 BC010047 AAH10047 BC029874 AAH29874 BC066895 AAH66895 DQ892419 ABM83345 DQ895633 ABM86559 HY027695 XM_011528060 XP_011526362 NM_016149 NM_015897 NP_056981
Function Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. {ECO:0000269|PubMed:12511558, ECO:0000269|PubMed:12631292, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:15831457, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:22508508}.
Subcellular Location Nucleus, PML body {ECO:0000269|PubMed:11248056, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:15831457}. Note=Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies.
Tissue Specificity Highly expressed in testis and, at lower levels, in spleen, prostate, ovary, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:11439351}.
Top Pathways Ubiquitin mediated proteolysis, Jak-STAT signaling pathway

PIASy CRISPR/Cas9 KO Plasmid (h) - sc-403125 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PIASy HDR Plasmid (h) - sc-403125-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PIASy Double Nickase Plasmid (h) - sc-403125-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PIASy Double Nickase Plasmid (h2) - sc-403125-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PIASy CRISPR Activation Plasmid (h) - sc-403125-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PIASy CRISPR Activation Plasmid (h2) - sc-403125-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PIASy Lentiviral Activation Particles (h) - sc-403125-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PIASy Lentiviral Activation Particles (h2) - sc-403125-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PIASy siRNA (h) - sc-40851 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PIASy shRNA Plasmid (h) - sc-40851-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PIASy shRNA (h) Lentiviral Particles - sc-40851-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU143671 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16776 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16776 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00803 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00803

PIAS4 siRNA (Human) - CRH9846 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PIASy RNAi - H00051588-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

PIASy CRISPR/Cas9 KO Plasmid (h2) - sc-403125-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PIASy HDR Plasmid (h2) - sc-403125-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human PIAS4 (NM_015897.2) - SHH375276 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PIAS4(NM_015897.2) - SHR113172 from Creative biogene

Category siRNA
Species Reactivities Human

Human PIAS4 siRNA - orb270348 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PIAS4 shRNA Plasmid (Human) - CHH9846 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PIAS4 miRNA 3'UTR clone - MiUTR1H-07883 from Creative biogene

Species Reactivities Human
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