PIAS4

Gene Symbol PIAS4
Entrez Gene 51588
Alt Symbol PIAS-gamma, PIASY, Piasg, ZMIZ6
Species Human
Gene Type protein-coding
Description protein inhibitor of activated STAT, 4
Other Description E3 SUMO-protein ligase PIAS4|protein inhibitor of activated STAT protein 4|protein inhibitor of activated STAT protein PIASy|protein inhibitor of activated STAT protein gamma|zinc finger, MIZ-type containing 6
Swissprots Q9UN16 O75926 Q96G19 Q8N2W9
Accessions EAW69273 Q8N2W9 AA758531 AF077952 AAC36703 AF164437 AAD45155 AK022481 BAG51076 AK222726 BAD96446 AK315530 BC004389 AAH04389 BC010047 AAH10047 BC029874 AAH29874 BC066895 AAH66895 DQ892419 ABM83345 DQ895633 ABM86559 HY027695 XM_011528060 XP_011526362 NM_016149 NM_015897 NP_056981
Function Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. {ECO:0000269|PubMed:12511558, ECO:0000269|PubMed:12631292, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:15831457, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:22508508}.
Subcellular Location Nucleus, PML body {ECO:0000269|PubMed:11248056, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:15831457}. Note=Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies.
Tissue Specificity Highly expressed in testis and, at lower levels, in spleen, prostate, ovary, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:11439351}.
Top Pathways Ubiquitin mediated proteolysis, Jak-STAT signaling pathway

PIAS4 (D2F12) Rabbit mAb - 4392 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2F12
Western blot analysis of extracts from 293 and CCRF-CEM cells using PIAS4 (D2F12) Rabbit mAb.

PIASy (H-9) - sc-376315 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PIASy (H-9): sc-376315. Western blot analysis of PIASy expression in non-transfected: sc-117752 (A) and human PIASy transfected: sc-114469 (B) 293T whole cell lysates.

PIASy (C-11) - sc-166706 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PIASy (C-11): sc-166706. Western blot analysis of PIASy expression in non-transfected: sc-117752 (A) and human PIASy transfected: sc-114469 (B) 293T whole cell lysates.

PIASy (F-20) - sc-18247 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PIASy (F-20): sc-18247. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing nuclear and cytoplasmic staining of cells in seminiferous ducts and Leydig cells.

PIASy (F-9) - sc-166744 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PIASy (F-9): sc-166744. Western blot analysis of PIASy expression in non-transfected: sc-117752 (A) and human PIASy transfected: sc-114469 (B) 293T whole cell lysates.

PIASy (H-75) - sc-50347 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PIASy (H-75): sc-50347. Western blot analysis of PIASy expression in non-transfected: sc-117752 (A) and human PIASy transfected: sc-114469 (B) 293T whole cell lysates.

PIASy (I-19) - sc-30876 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PIASy (I-19): sc-30876. Western blot analysis of PIASy expression in non-transfected: sc-117752 (A) and human PIASy transfected: sc-114469 (B) 293T whole cell lysates.

PIASy (P-18) - sc-30875 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PIASy (P-18): sc-30875. Western blot analysis of PIASy expression in non-transfected: sc-117752 (A) and human PIASy transfected: sc-114469 (B) 293T whole cell lysates.

Anti-E3 SUMO-protein ligase PIAS4 antibody - ab58416 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-E3 SUMO-protein ligase PIAS4 antibody (ab58416) at 1/500 dilutionLane 1 : Jurkat cell extract without immunizing peptideLane 2 : Jurkat cell extract with immunizing peptide

Anti-E3 SUMO-protein ligase PIAS4 antibody - ab137500 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-E3 SUMO-protein ligase PIAS4 antibody (ab137500) at 1/1000 dilutionLane 1 : HeLaS3 whole cell lysateLane 2 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-E3 SUMO-protein ligase PIAS4 antibody - ab38622 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-E3 SUMO-protein ligase PIAS4 antibody (ab38622) + Recombinant GST-PIASy-1(81.4 kDa) in bacterial cell lysate.

Anti-E3 SUMO-protein ligase PIAS4 antibody - ab13795 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-E3 SUMO-protein ligase PIAS4 antibody [7B8] - ab134765 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7B8
Anti-E3 SUMO-protein ligase PIAS4 antibody [7B8] (ab134765) at 1/1000 dilution + MEF cell lysate

Anti-E3 SUMO-protein ligase PIAS4 antibody [PIA4] - ab61405 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone PIA4

Anti-PIAS4 / PIASY Antibody (aa44-73, AP) - LS-C239021 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIAS4 / PIASY Antibody (aa44-73, APC) - LS-C239022 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIAS4 / PIASY Antibody (aa44-73, FITC) - LS-C239023 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIAS4 / PIASY Antibody (aa44-73, Biotin) - LS-C239024 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIAS4 / PIASY Antibody (aa44-73, PE) - LS-C239025 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIAS4 / PIASY Antibody (aa56-86, AP) - LS-C239026 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIAS4 / PIASY Antibody (aa56-86, APC) - LS-C239027 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIAS4 / PIASY Antibody (aa48-79) - LS-C98800 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-PIAS4 / PIASY Antibody (aa56-86, Biotin) - LS-C239028 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIAS4 / PIASY Antibody (aa56-86, FITC) - LS-C239029 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIAS4 / PIASY Antibody (aa56-86, PE) - LS-C239034 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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