GPR143

Gene Symbol GPR143
Entrez Gene 4935
Alt Symbol NYS6, OA1
Species Human
Gene Type protein-coding
Description G protein-coupled receptor 143
Other Description G-protein coupled receptor 143|ocular albinism 1|ocular albinism type 1 protein
Swissprots P51810 Q6NTI7
Accessions EAW98773 P51810 BC015657 BC068977 AAH68977 BU188283 Z48804 CAA88742 XM_005274541 XP_005274598 NM_000273 NP_000264
Function Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. {ECO:0000269|PubMed:10471510, ECO:0000269|PubMed:16524428, ECO:0000269|PubMed:18697795, ECO:0000269|PubMed:18828673, ECO:0000269|PubMed:19717472}.
Subcellular Location Golgi apparatus. Melanosome membrane; Multi- pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Distributed throughout the endo-melanosomal system but most of endogenous protein is localized in unpigmented stage II melanosomes. Its expression on the apical cell membrane is sensitive to tyrosine.
Tissue Specificity Expressed at high levels in the retina, including the retinal pigment epithelium (RPE), and in melanocytes. Weak expression is observed in brain and adrenal gland. {ECO:0000269|PubMed:18828673, ECO:0000269|PubMed:7647783}.

OA1 (C-6) - sc-398602 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
OA1 (C-6): sc-398602. Western blot analysis of OA1 expression in human prostate tissue extract.

OA1 (N-16) - sc-47261 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

OA1 (K-16) - sc-47258 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OA1 (K-16): sc-47258. Western blot analysis of OA1 expression in human prostate tissue extract.

OA1 (C-20) - sc-47257 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-OA1 antibody - ab65635 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-OA1 antibody - ab81112 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-OA1 antibody - ab169746 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-OA1 antibody (ab169746) at 1 µg/mlLane 1 : Transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-mouse HRP at 1/2500 dilution

Anti-GPR143 Antibody (Cytoplasmic Domain) - LS-C94187 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-GPR143 Antibody (aa151-200) - LS-C120688 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of LOVO cells, using GPR143 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-GPR143 Antibody - LS-C136950 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GPR143 Antibody (C-Terminus) IHC-plus™ - LS-A2128 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPR143 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

OA1 Antibody - H00004935-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: OA1 Antibody [H00004935-B01] - analysis of GPR143 expression in transfected 293T cell line by GPR143 MaxPab polyclonal antibody. Lane 1: GPR143 transfected lysate (46.64 KDa). Lane 2: Non-transfected lysate.

OA1 Antibody - H00004935-B01P from Novus Biologicals

Prices $349.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: OA1 Antibody [H00004935-B01P] - analysis of GPR143 expression in transfected 293T cell line by GPR143 MaxPab polyclonal antibody. Lane 1: GPR143 transfected lysate (46.64 KDa). Lane 2: Non-transfected lysate.

Anti-GPR143 antibody produced in rabbit - SAB2900506 from Sigma-Aldrich

Prices $465.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-GPR143 (N-Terminus), antibody produced in rabbit: <B>Cat. No. SAB2900506</B>: Anti-GPR143 antibody IHC staining of human eye, retina. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GPR143 antibody produced in rabbit - SAB4502037 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-GPR143: <B>Cat. No. SAB4502037</B>: Immunofluorescence of LOVO cells using Anti-GPR143 antibody. Cells on the left were treated with the Anti-GPR143 antibody. Cells on the right (negative control) were treated with both Anti-GPR143 antibody and the synthesized immunogen peptide.

Anti-GPR143 antibody produced in mouse - SAB1401269 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Histogram</B><BR/>Polyclonal Anti-GPR143, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1401269</B>: Antibody concentration: 1.0 μg/mL using GPR143 expressing HEK 293 cells. Green line represents transfected HEK 293 cells, and black line represents non-transfected (negative control) HEK 293 cells.

Anti-GPR143 antibody produced in rabbit - HPA003648 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-GPR143:<B>Cat. No. HPA003648</B>: Immunohistochemical staining of human skin shows moderate cytoplasmic positivity in melanocytes.

GPR143 Antibody (OAAF04919) - OAAF04919 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

GPR143 antibody - orb77284 from Biorbyt

Prices $425.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Western blot analysis of Hela lysates using GPR143 antibody

Anti -GPR143 (G-protein Coupled Receptor 143, Ocular Albinism Type 1 Protein, OA1) - 170635 from USBiological Life Science

Host Rabbit
Clonality Polyclonal

GPR143 antibody - orb85567 from Biorbyt

Prices $536.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Immunohistochemical staining of paraffin embedded human eye retina tissue using GPR143 antibody (primary antibody at 1:200)

GPR143 Antibody (OALA00418) - OALA00418 from Aviva Systems Biology

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

GPR143 Antibody - abx121122 from Abbexa

Host Rabbit
Clonality Polyclonal

gpr143 Antibody - abx038139 from Abbexa

Host Rabbit
Clonality Polyclonal

GPR143 / OA1 antibody - H00004935-B01 from Acris Antibodies

Prices $360.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot analysis of GPR143 expression in transfected 293T cell line (H00004935-T01) by GPR143 MaxPab polyclonal antibody. Lane 1: GPR143 transfected lysate(46.64 KDa). Lane 2: Non-transfected lysate.
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