GPR143

Gene Symbol GPR143
Entrez Gene 4935
Alt Symbol NYS6, OA1
Species Human
Gene Type protein-coding
Description G protein-coupled receptor 143
Other Description G-protein coupled receptor 143|ocular albinism 1|ocular albinism type 1 protein
Swissprots P51810 Q6NTI7
Accessions EAW98773 P51810 BC015657 BC068977 AAH68977 BU188283 Z48804 CAA88742 XM_005274541 XP_005274598 NM_000273 NP_000264
Function Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. {ECO:0000269|PubMed:10471510, ECO:0000269|PubMed:16524428, ECO:0000269|PubMed:18697795, ECO:0000269|PubMed:18828673, ECO:0000269|PubMed:19717472}.
Subcellular Location Golgi apparatus. Melanosome membrane; Multi- pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Distributed throughout the endo-melanosomal system but most of endogenous protein is localized in unpigmented stage II melanosomes. Its expression on the apical cell membrane is sensitive to tyrosine.
Tissue Specificity Expressed at high levels in the retina, including the retinal pigment epithelium (RPE), and in melanocytes. Weak expression is observed in brain and adrenal gland. {ECO:0000269|PubMed:18828673, ECO:0000269|PubMed:7647783}.

OA1 CRISPR/Cas9 KO Plasmid (h) - sc-410913 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OA1 HDR Plasmid (h) - sc-410913-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OA1 Double Nickase Plasmid (h) - sc-410913-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OA1 Double Nickase Plasmid (h2) - sc-410913-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OA1 CRISPR Activation Plasmid (h) - sc-410913-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OA1 CRISPR Activation Plasmid (h2) - sc-410913-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OA1 Lentiviral Activation Particles (h) - sc-410913-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OA1 Lentiviral Activation Particles (h2) - sc-410913-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OA1 siRNA (h) - sc-61239 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OA1 shRNA Plasmid (h) - sc-61239-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OA1 shRNA (h) Lentiviral Particles - sc-61239-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OA1 RNAi - H00004935-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU132271 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1669 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1669 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02022 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02022

GPR143 siRNA (Human) - CRH3281 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GPR143 - MBS8205814 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GPR143 (NM_000273.2) - SHH306334 from Creative biogene

Category siRNA
Species Reactivities Human

GPR143 shRNA Plasmid (Human) - CHH3281 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GPR143 miRNA 3'UTR clone - MiUTR3H-02941 from Creative biogene

Species Reactivities Human
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