GPR143

Gene Symbol	GPR143
Entrez Gene	4935
Alt Symbol	NYS6, OA1
Species	Human
Gene Type	protein-coding
Description	G protein-coupled receptor 143
Other Description	G-protein coupled receptor 143|ocular albinism 1|ocular albinism type 1 protein
Swissprots	P51810 Q6NTI7
Accessions	EAW98773 P51810 BC015657 BC068977 AAH68977 BU188283 Z48804 CAA88742 XM_005274541 XP_005274598 NM_000273 NP_000264
Function	Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. {ECO:0000269|PubMed:10471510, ECO:0000269|PubMed:16524428, ECO:0000269|PubMed:18697795, ECO:0000269|PubMed:18828673, ECO:0000269|PubMed:19717472}.
Subcellular Location	Golgi apparatus. Melanosome membrane; Multi- pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Distributed throughout the endo-melanosomal system but most of endogenous protein is localized in unpigmented stage II melanosomes. Its expression on the apical cell membrane is sensitive to tyrosine.
Tissue Specificity	Expressed at high levels in the retina, including the retinal pigment epithelium (RPE), and in melanocytes. Weak expression is observed in brain and adrenal gland. {ECO:0000269|PubMed:18828673, ECO:0000269|PubMed:7647783}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human OA1 full length protein - ab159020 from Abcam Category Protein Source Wheat germ Species Human

GPR143 Antibody Blocking Peptide - LS-E28509 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human OA1 Protein - H00004935-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human OA1 Protein - H00004935-G01 from Novus Biologicals Category Protein Prices $569.00 Sizes 10 µg Source Wheat Germ Species Human

GPR143 Blocking Peptide - abx161122 from Abbexa Category Peptide Species Human, Mouse, Rat

GPR143 / OA1 - H00004935-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

GPR143 / OA1 - H00004935-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

GPR143 fusion protein - ag11971 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

GPR143 fusion protein - ag11994 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

GPR143 fusion protein - Ag14290 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

GPR143 fusion protein - Ag14819 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

GPR143 Blocking Peptide - CBP3621 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

OA1 Protein - NBP2-14066PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

GPR143 Peptide, Human - M34GP06533H from Creative Peptides Category Peptide Source Synthetic. Species Human

G-protein coupled receptor 143 (GPR143), Recombinant Protein - MBS7016095 from MyBioSource Category Protein Prices $1,210.00, $2,195.00, $3,400.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

G-protein coupled receptor 143 (GPR143), Recombinant Protein - MBS956653 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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