| Gene Symbol |
GPR143
|
| Entrez Gene |
4935
|
| Alt Symbol |
NYS6, OA1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G protein-coupled receptor 143
|
| Other Description |
G-protein coupled receptor 143|ocular albinism 1|ocular albinism type 1 protein
|
| Swissprots |
P51810 Q6NTI7
|
| Accessions |
EAW98773 P51810 BC015657 BC068977 AAH68977 BU188283 Z48804 CAA88742 XM_005274541 XP_005274598 NM_000273 NP_000264
|
| Function |
Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. {ECO:0000269|PubMed:10471510, ECO:0000269|PubMed:16524428, ECO:0000269|PubMed:18697795, ECO:0000269|PubMed:18828673, ECO:0000269|PubMed:19717472}.
|
| Subcellular Location |
Golgi apparatus. Melanosome membrane; Multi- pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Distributed throughout the endo-melanosomal system but most of endogenous protein is localized in unpigmented stage II melanosomes. Its expression on the apical cell membrane is sensitive to tyrosine.
|
| Tissue Specificity |
Expressed at high levels in the retina, including the retinal pigment epithelium (RPE), and in melanocytes. Weak expression is observed in brain and adrenal gland. {ECO:0000269|PubMed:18828673, ECO:0000269|PubMed:7647783}.
|