Gene Symbol | CYB5R4 |
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Entrez Gene | 51167 |
Alt Symbol | NCB5OR, cb5/cb5R, dJ676J13.1 |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome b5 reductase 4 |
Other Description | N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein|NADPH cytochrome B5 oxidoreductase|cytochrome b-type NAD(P)H oxidoreductase|flavohemoprotein b5+b5R|flavohemoprotein b5/b5R |
Swissprots | Q9UHI9 Q9NUE4 Q5TGI9 B1AEM2 Q7L1T6 |
Accessions | ACA06109 Q7L1T6 AF169803 AAF04812 AK313146 BAG35964 AL832113 AM393033 CAL37911 BC025380 AAH25380 BC029339 DA274558 DQ892067 ABM82993 DQ895260 ABM86186 NM_016230 NP_057314 |
Function | NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin. |
Subcellular Location | Endoplasmic reticulum {ECO:0000269|PubMed:10611283, ECO:0000269|PubMed:15131110}. Note=Soluble protein. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:10611283}. |
Top Pathways | Amino sugar and nucleotide sugar metabolism |
NCB5OR (D-2) - sc-390569 from Santa Cruz Biotechnology
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NCB5OR (D-4) - sc-390570 from Santa Cruz Biotechnology
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NCB5OR (H-191) - sc-366699 from Santa Cruz Biotechnology
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NCB5OR (M-60) - sc-367404 from Santa Cruz Biotechnology
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NCB5OR (N-18) - sc-68684 from Santa Cruz Biotechnology
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NCB5OR (L-15) - sc-68683 from Santa Cruz Biotechnology
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NCB5OR (V-14) - sc-68686 from Santa Cruz Biotechnology
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NCB5OR (L-7) - sc-100529 from Santa Cruz Biotechnology
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Anti-CYB5R4 antibody - ab101342 from Abcam
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Anti-CYB5R4 antibody - ab57286 from Abcam
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Anti-CYB5R4 Antibody (N-Terminus) - LS-C135412 from LifeSpan Bioscience
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Anti-CYB5R4 Antibody (aa388-488, clone 10B2625, Azide-free) - LS-C183549 from LifeSpan Bioscience
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Anti-CYB5R4 Antibody (aa388-488) - LS-C307147 from LifeSpan Bioscience
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Anti-CYB5R4 Antibody (aa444-458) - LS-C155001 from LifeSpan Bioscience
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CYB5R4 Antibody - NBP1-88957 from Novus Biologicals
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CYB5R4 Antibody (1E8) - H00051167-M01 from Novus Biologicals
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CYB5R4 Antibody - NBP2-16049 from Novus Biologicals
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CYB5R4 Antibody - H00051167-A01 from Novus Biologicals
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CYB5R4 Antibody (4B8) - H00051167-M02A from Novus Biologicals
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CYB5R4 Polyclonal Antibody - bs-14133R from Bioss
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Anti-CYB5R4 antibody produced in rabbit - SAB2701390 from Sigma-Aldrich
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Anti-CYB5R4 antibody produced in rabbit - HPA018992 from Sigma-Aldrich
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Monoclonal Anti-CYB5R4 antibody produced in mouse - WH0051167M1 from Sigma-Aldrich
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CYB5R4-Antibody-monoclonal-M01 - AT1697a from Abgent, a WuXi AppTec company
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CYB5R4 antibody [C1C3] - GTX119151 from GeneTex
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