Gene Symbol | CYB5R4 |
---|---|
Entrez Gene | 51167 |
Alt Symbol | NCB5OR, cb5/cb5R, dJ676J13.1 |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome b5 reductase 4 |
Other Description | N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein|NADPH cytochrome B5 oxidoreductase|cytochrome b-type NAD(P)H oxidoreductase|flavohemoprotein b5+b5R|flavohemoprotein b5/b5R |
Swissprots | Q9UHI9 Q9NUE4 Q5TGI9 B1AEM2 Q7L1T6 |
Accessions | ACA06109 Q7L1T6 AF169803 AAF04812 AK313146 BAG35964 AL832113 AM393033 CAL37911 BC025380 AAH25380 BC029339 DA274558 DQ892067 ABM82993 DQ895260 ABM86186 NM_016230 NP_057314 |
Function | NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin. |
Subcellular Location | Endoplasmic reticulum {ECO:0000269|PubMed:10611283, ECO:0000269|PubMed:15131110}. Note=Soluble protein. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:10611283}. |
Top Pathways | Amino sugar and nucleotide sugar metabolism |
NCB5OR CRISPR/Cas9 KO Plasmid (h) - sc-409572 from Santa Cruz Biotechnology
|
||||||||
NCB5OR HDR Plasmid (h) - sc-409572-HDR from Santa Cruz Biotechnology
|
||||||||
NCB5OR Double Nickase Plasmid (h) - sc-409572-NIC from Santa Cruz Biotechnology
|
||||||||
NCB5OR Double Nickase Plasmid (h2) - sc-409572-NIC-2 from Santa Cruz Biotechnology
|
||||||||
NCB5OR CRISPR Activation Plasmid (h) - sc-409572-ACT from Santa Cruz Biotechnology
|
||||||||
NCB5OR CRISPR Activation Plasmid (h2) - sc-409572-ACT-2 from Santa Cruz Biotechnology
|
||||||||
NCB5OR Lentiviral Activation Particles (h) - sc-409572-LAC from Santa Cruz Biotechnology
|
||||||||
NCB5OR Lentiviral Activation Particles (h2) - sc-409572-LAC-2 from Santa Cruz Biotechnology
|
||||||||
NCB5OR siRNA (h) - sc-75883 from Santa Cruz Biotechnology
|
||||||||
NCB5OR shRNA Plasmid (h) - sc-75883-SH from Santa Cruz Biotechnology
|
||||||||
NCB5OR shRNA (h) Lentiviral Particles - sc-75883-V from Santa Cruz Biotechnology
|
||||||||
CYB5R4 RNAi - H00051167-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU008981 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN6853 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6853 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR04957 from Sigma-Aldrich
|
||||||||
CYB5R4 siRNA (Human) - CRH9577 from Cohesion Biosciences
|
||||||||
CYB5R4 - MBS8216983 from MyBioSource
|
||||||||
shRNA set against Human CYB5R4 (NM_016230.3) - SHH272617 from Creative biogene
|
||||||||
Human CYB5R4 siRNA - orb270079 from Biorbyt
|
||||||||
CYB5R4 shRNA Plasmid (Human) - CHH9577 from Cohesion Biosciences
|
||||||||
CYB5R4 miRNA 3'UTR clone - MiUTR1H-02596 from Creative biogene
|