Gene Symbol | CYB5R4 |
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Entrez Gene | 51167 |
Alt Symbol | NCB5OR, cb5/cb5R, dJ676J13.1 |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome b5 reductase 4 |
Other Description | N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein|NADPH cytochrome B5 oxidoreductase|cytochrome b-type NAD(P)H oxidoreductase|flavohemoprotein b5+b5R|flavohemoprotein b5/b5R |
Swissprots | Q9UHI9 Q9NUE4 Q5TGI9 B1AEM2 Q7L1T6 |
Accessions | ACA06109 Q7L1T6 AF169803 AAF04812 AK313146 BAG35964 AL832113 AM393033 CAL37911 BC025380 AAH25380 BC029339 DA274558 DQ892067 ABM82993 DQ895260 ABM86186 NM_016230 NP_057314 |
Function | NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin. |
Subcellular Location | Endoplasmic reticulum {ECO:0000269|PubMed:10611283, ECO:0000269|PubMed:15131110}. Note=Soluble protein. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:10611283}. |
Top Pathways | Amino sugar and nucleotide sugar metabolism |
Human CYB5R4 full length protein - ab162439 from Abcam
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Human CYB5R4 protein fragment - ab162440 from Abcam
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CYB5R4 Antibody Blocking Peptide - LS-E27873 from LifeSpan Bioscience
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CYB5R4 Antibody Blocking Peptide - LS-E20709 from LifeSpan Bioscience
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CYB5R4 Recombinant Protein - H00051167-P01 from Novus Biologicals
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Recombinant Human CYB5R4 Protein - H00051167-Q01 from Novus Biologicals
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Cyb5r4 Blocking Peptide - 33R-7364 from Fitzgerald
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CYB5R4 - H00051167-P01-10 from Acris Antibodies
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CYB5R4 - H00051167-P01-25 from Acris Antibodies
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CYB5R4 - H00051167-Q01-10 from Acris Antibodies
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CYB5R4 - H00051167-Q01-25 from Acris Antibodies
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CYB5R4 fusion protein - Ag3318 from Proteintech Group
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Recombinant Human Cytochrome b5 reductase 4(CYB5R4) - CSB-YP006321HU CSB-EP006321HU CSB-BP006321HU CSB-MP006321HU from Cusabio
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CYB5R4 - TP305203 from Acris Antibodies
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CYB5R4 Recombinant Protein Antigen - NBP1-88957PEP from Novus Biologicals
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CYB5R4 Peptide, Human - M34GP03921H from Creative Peptides
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Cytochrome b5 reductase 4 (CYB5R4), Recombinant Protein - MBS1297756 from MyBioSource
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Cyb5r4 Immunizing peptide - orb66384 from Biorbyt
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