| Gene Symbol |
CYB5R4
|
| Entrez Gene |
51167
|
| Alt Symbol |
NCB5OR, cb5/cb5R, dJ676J13.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome b5 reductase 4
|
| Other Description |
N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein|NADPH cytochrome B5 oxidoreductase|cytochrome b-type NAD(P)H oxidoreductase|flavohemoprotein b5+b5R|flavohemoprotein b5/b5R
|
| Swissprots |
Q9UHI9 Q9NUE4 Q5TGI9 B1AEM2 Q7L1T6
|
| Accessions |
ACA06109 Q7L1T6 AF169803 AAF04812 AK313146 BAG35964 AL832113 AM393033 CAL37911 BC025380 AAH25380 BC029339 DA274558 DQ892067 ABM82993 DQ895260 ABM86186 NM_016230 NP_057314
|
| Function |
NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.
|
| Subcellular Location |
Endoplasmic reticulum {ECO:0000269|PubMed:10611283, ECO:0000269|PubMed:15131110}. Note=Soluble protein.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:10611283}.
|
| Top Pathways |
Amino sugar and nucleotide sugar metabolism
|