ATP5E
| Gene Symbol | ATP5E |
|---|---|
| Entrez Gene | 514 |
| Alt Symbol | ATPE, MC5DN3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit |
| Other Description | ATP synthase subunit epsilon, mitochondrial|F(0)F(1)-ATPase|H(+)-transporting two-sector ATPase|mitochondrial ATP synthase epsilon chain|mitochondrial ATPase |
| Swissprots | Q53XU6 P56381 E1P5H6 B2RDD0 |
| Accessions | EAW75444 EAW75445 EAW75446 P56381 AF052955 AAF72736 AF077045 AAD27778 AK026556 AK315493 BAG37877 BC001690 AAH01690 BC003671 AAH03671 BC070167 BC105811 AAI05812 BT007293 AAP35957 CB106920 DA202623 NM_006886 NP_008817 |
| Function | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity). {ECO:0000250}. |
| Subcellular Location | Mitochondrion. Mitochondrion inner membrane. |
| Tissue Specificity | Ubiquitous. |
| Top Pathways | Alzheimer's disease, Huntington's disease, Oxidative phosphorylation |
ATP5E CRISPR/Cas9 KO Plasmid (h) - sc-418591 from Santa Cruz Biotechnology
|
||||||||
ATP5E HDR Plasmid (h) - sc-418591-HDR from Santa Cruz Biotechnology
|
||||||||
ATP5E Double Nickase Plasmid (h) - sc-418591-NIC from Santa Cruz Biotechnology
|
||||||||
ATP5E Double Nickase Plasmid (h2) - sc-418591-NIC-2 from Santa Cruz Biotechnology
|
||||||||
ATP5E CRISPR Activation Plasmid (h) - sc-418591-ACT from Santa Cruz Biotechnology
|
||||||||
ATP5E CRISPR Activation Plasmid (h2) - sc-418591-ACT-2 from Santa Cruz Biotechnology
|
||||||||
ATP5E Lentiviral Activation Particles (h) - sc-418591-LAC from Santa Cruz Biotechnology
|
||||||||
ATP5E Lentiviral Activation Particles (h2) - sc-418591-LAC-2 from Santa Cruz Biotechnology
|
||||||||
ATP5E siRNA (h) - sc-60229 from Santa Cruz Biotechnology
|
||||||||
ATP5E shRNA Plasmid (h) - sc-60229-SH from Santa Cruz Biotechnology
|
||||||||
ATP5E shRNA (h) Lentiviral Particles - sc-60229-V from Santa Cruz Biotechnology
|
||||||||
ATP5E RNAi - H00000514-R02 from Novus Biologicals
|
||||||||
ATP5E RNAi - H00000514-R01 from Novus Biologicals
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN3698 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3698 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR00962 from Sigma-Aldrich
|
||||||||
ATP5E siRNA (Human) - CRH0355 from Cohesion Biosciences
|
||||||||
ATP5E - MBS8212401 from MyBioSource
|
||||||||
shRNA set against Human ATP5E (NM_006886.3) - SHH242782 from Creative biogene
|
||||||||
Human ATP5E siRNA - orb260857 from Biorbyt
|
||||||||
ATP5E shRNA Plasmid (Human) - CHH0355 from Cohesion Biosciences
|
||||||||
ATP5E miRNA 3'UTR clone - MiUTR3H-08259 from Creative biogene
|