NPPB

Gene Symbol NPPB
Entrez Gene 4879
Alt Symbol BNP
Species Human
Gene Type protein-coding
Description natriuretic peptide B
Other Description brain type natriuretic peptide|gamma-brain natriuretic peptide|natriuretic peptide precursor B|natriuretic peptides B|natriuretic protein
Swissprots Q9P2Q7 B0ZBE9 P16860 Q6FGY0
Accessions AAA35603 ACA05917 BAA04067 BAA90441 BAD06457 BAF64842 EAW71718 EAW71719 P16860 AJ708502 BC025785 AAH25785 CR541976 CAG46774 CR542003 CAG46800 M25296 AAA36355 NM_002521 NP_002512
Function Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. {ECO:0000269|PubMed:1672777}.
Subcellular Location Secreted.
Tissue Specificity Brain and also in atria, but at much lower levels than ANP.
Top Pathways cGMP-PKG signaling pathway

BNP (D-8) - sc-271185 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BNP (D-8): sc-271185. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

BNP (N-10) - sc-18813 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BNP (N-10): sc-18813. Western blot analysis of BNP expression in U-87 MG whole cell lysate.

BNP (C-11) - sc-18814 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BNP (C-11): sc-18814. Western blot analysis of BNP expression in U-87 MG whole cell lysate.

BNP (FL-134) - sc-20159 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
BNP (FL-134): sc-20159. Western blot analysis of BNP expression in U-87 MG whole cell lysate.

BNP (8D5B4C11) - sc-101418 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BNP (8D5B4C11): sc-101418. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human normal myocardium tissue showing cytoplasmic localization.

Anti-BNP antibody - ab19645 from Abcam

Prices $379.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-BNP antibody (ab19645) at 1/500 dilutionLane 1 : SK N BE (Human neuroblastoma) Whole Cell LysateLane 2 : TE 671 (Human Rhabdomyosarcoma) Whole Cell Lysate Lane 3 : SW480 (Human colon adenocarcinoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Anti-BNP antibody - ab19646 from Abcam

Prices $378.00
Sizes 25 µl
Host Rabbit
Clonality Polyclonal
ab19646 staining BN{ in human differentiated cardiac stem cells by Flow Cytometry. Cells were fixed with paraformaldehyde and permeabilized with permeabilization buffer. The sample was incubated with the primary antibody (1/600 in permeabilization buffer) for 1 hour at 4°C. An Alexa Fluor® 488-conjugated goat polyclonal anti-rabbit IgG (1/300) was used as the secondary antibody.Gating Strategy: Isotype negative control (white).See Abreview

Anti-BNP antibody - ab47699 from Abcam

Prices $370.00
Sizes 150 µg
Host Rabbit
Clonality Polyclonal

Anti-BNP antibody - ab66240 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
All lanes : Anti-BNP antibody (ab66240) at 1 µg/mlLane 1 : BNP transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 50 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-BNP antibody - ab97787 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-BNP antibody (ab97787) at 1/1000 dilutionLane 1 : HeLa whole cell lysateLane 2 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-BNP antibody - ab14358 from Abcam

Prices $368.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-BNP antibody [24C5] (HRP) - ab14699 from Abcam

Prices $372.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone 24C5

Anti-BNP antibody [26E2] - ab25977 from Abcam

Prices $370.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone 26E2

Anti-BNP antibody [26E2] (HRP) - ab14701 from Abcam

Prices $370.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone 26E2

Anti-BNP antibody [50E1] - ab20984 from Abcam

Prices $373.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 50E1

Anti-BNP antibody [8D5B4C11] - ab63341 from Abcam

Host Mouse
Clonality Monoclonal
Clone 8D5B4C11
ab63341, at a concentration of 1/500, staining BNP on human normal myocardium paraffin embedded tissue by immunohistochemistry using DAB staining.

Anti-BNP antibody (Biotin) - ab47850 from Abcam

Prices $370.00
Sizes 150 µg
Host Rabbit
Clonality Polyclonal

Anti-BNP antibody (Biotin) - ab193136 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BNP antibody [EP3737(2)] - C-terminal - ab173284 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP3737(2)
Anti-BNP antibody [EP3737(2)] - C-terminal (ab173284) at 1/10000 dilution + BNP polypeptide at 0.00499999988824 µgdeveloped using the ECL technique

Anti-BNP antibody [EPR3735] - ab92500 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3735
All lanes : Anti-BNP antibody [EPR3735] (ab92500) at 1/2000 dilutionLane 1 : Human plasmaLane 2 : Human fetal heart lysateLysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP at 1/2000 dilution

Anti-BNP antibody [EPR3736] - ab174856 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3736
Anti-BNP antibody [EPR3736] (ab174856) at 1/1000 dilution + Human BNP at 0.01 µg

Anti-BNP/ProBNP antibody - ab125269 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-BNP/ProBNP antibody (ab125269) at 1/500 dilution + Recombinant full length Human BNP/ProBNP recombinant protein

Anti-BNP/ProBNP antibody - ab105181 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-BNP/ProBNP antibody (ab105181) at 1 µg/mlLane 1 : Heart (Human) Tissue Lysate - adult normal tissue (ab29431)Lane 2 : Heart (Human) Tissue Lysate - adult normal tissue (ab29431) with Immunising peptide at 1 µg/mlLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-BNP/ProBNP antibody - C-terminal - ab196343 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-proBNP antibody - ab32842 from Abcam

Prices $372.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
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