| Gene Symbol |
NPPB
|
| Entrez Gene |
4879
|
| Alt Symbol |
BNP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
natriuretic peptide B
|
| Other Description |
brain type natriuretic peptide|gamma-brain natriuretic peptide|natriuretic peptide precursor B|natriuretic peptides B|natriuretic protein
|
| Swissprots |
Q9P2Q7 B0ZBE9 P16860 Q6FGY0
|
| Accessions |
AAA35603 ACA05917 BAA04067 BAA90441 BAD06457 BAF64842 EAW71718 EAW71719 P16860 AJ708502 BC025785 AAH25785 CR541976 CAG46774 CR542003 CAG46800 M25296 AAA36355 NM_002521 NP_002512
|
| Function |
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. {ECO:0000269|PubMed:1672777}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Brain and also in atria, but at much lower levels than ANP.
|
| Top Pathways |
cGMP-PKG signaling pathway
|
![Western Blot: proBNP Overexpression Lysate (Adult Normal) [NBL1-13753] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for proBNP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4575_proBNP%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13753-img0002.jpg)