DGAT2

Gene Symbol DGAT2
Entrez Gene 84649
Alt Symbol ARAT, GS1999FULL, HMFN1045
Species Human
Gene Type protein-coding
Description diacylglycerol O-acyltransferase 2
Other Description acyl-CoA retinol O-fatty-acyltransferase|diacylglycerol O-acyltransferase homolog 2|diacylglycerol O-acyltransferase-like protein 2|diglyceride acyltransferase 2|retinol O-fatty-acyltransferase
Swissprots Q8NDB7 Q68CL3 Q96PD7 Q68DJ0 Q9BYE5 Q5U810 A6ND76 Q96BS0
Accessions CBF67543 CBF90902 CBU92416 CBV04422 EAW74984 EAW74985 Q96PD7 AB048286 BAB40641 AB073384 BAD38635 AF384161 AAK84176 AI126704 AK074203 AK091870 AL834287 CAD38961 AY358532 AAQ88896 AY780646 AY780647 AAV35727 BC015234 AAH15234 CR749377 CAH18230 DB462004 HQ448288 ADQ32768 XM_011545304 XP_011543606 NM_001253891 NP_001240820 NM_032564 NP_115953
Function Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT). {ECO:0000250}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:14521909}; Multi-pass membrane protein {ECO:0000269|PubMed:14521909}. Lipid droplet {ECO:0000250}.
Tissue Specificity Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin. {ECO:0000269|PubMed:11481335, ECO:0000269|PubMed:14521909}.
Top Pathways Fat digestion and absorption, Glycerolipid metabolism

DGAT2 (A-18) - sc-32399 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DGAT2 (A-18): sc-32399. Immunoperoxidase staining of formalin fixed, paraffin-embedded human hippocampus tissue showing cytoplasmic staining of neuronal cells and Glial cells.

DGAT2 (C-15) - sc-32400 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DGAT2 (C-15): sc-32400. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining of cells in tubules.

DGAT2 (H-70) - sc-66859 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DGAT2 (H-70): sc-66859. Immunoperoxidase staining of formalin fixed, paraffin-embedded human seminal vesicle tissue showing cytoplasmic staining of glandular cells.

Anti-DGAT2 antibody - ab102831 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-DGAT2 antibody (ab102831) at 1/100 dilution + NCI-H460 cell line lysate at 35 µg

Anti-DGAT2 Antibody (aa153-388) - LS-C185764 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded A549 xenograft using DGAT2 antibody at 1:100 dilution.

Anti-DGAT2 Antibody (aa303-316) IHC-plus™ - LS-B3974 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-DGAT2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3974 concentration 3.75 ug/ml.

Anti-DGAT2 Antibody (Biotin) - LS-C180645 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DGAT2 Antibody (DY650) - LS-C180646 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DGAT2 Antibody (DY488) - LS-C180647 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DGAT2 Antibody (HRP) - LS-C180648 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DGAT2 Antibody (DY550) - LS-C180649 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DGAT2 Antibody - LS-C180107 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DGAT2 Antibody - Analysis of DGAT2 in human liver lysate.

Anti-DGAT2 Antibody (Biotin) - LS-C180650 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DGAT2 Antibody (DY650) - LS-C180651 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DGAT2 Antibody (HRP) - LS-C180653 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DGAT2 Antibody (DY488) - LS-C180652 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DGAT2 Antibody (DY550) - LS-C180654 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DGAT2 Antibody (aa1-30) - LS-C167377 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of DGAT2 Antibody in NCI-H460 cell line lysates (35 ug/lane). DGAT2 (arrow) was detected using the purified antibody.

Anti-DGAT2 Antibody (aa1-30, AP) - LS-C259183 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DGAT2 Antibody (aa1-30, APC) - LS-C259184 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DGAT2 Antibody - LS-C180108 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DGAT2 Antibody - Analysis of DGAT2 in A. human liver lysate and B. mouse brain lysate.

Anti-DGAT2 Antibody (aa1-30, FITC) - LS-C259185 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DGAT2 Antibody (aa1-30, PE) - LS-C259188 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DGAT2 Antibody (aa289-389) - LS-C307225 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-DGAT2 Antibody (aa4-34) - LS-C320815 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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