DGAT2

Gene Symbol DGAT2
Entrez Gene 84649
Alt Symbol ARAT, GS1999FULL, HMFN1045
Species Human
Gene Type protein-coding
Description diacylglycerol O-acyltransferase 2
Other Description acyl-CoA retinol O-fatty-acyltransferase|diacylglycerol O-acyltransferase homolog 2|diacylglycerol O-acyltransferase-like protein 2|diglyceride acyltransferase 2|retinol O-fatty-acyltransferase
Swissprots Q8NDB7 Q68CL3 Q96PD7 Q68DJ0 Q9BYE5 Q5U810 A6ND76 Q96BS0
Accessions CBF67543 CBF90902 CBU92416 CBV04422 EAW74984 EAW74985 Q96PD7 AB048286 BAB40641 AB073384 BAD38635 AF384161 AAK84176 AI126704 AK074203 AK091870 AL834287 CAD38961 AY358532 AAQ88896 AY780646 AY780647 AAV35727 BC015234 AAH15234 CR749377 CAH18230 DB462004 HQ448288 ADQ32768 XM_011545304 XP_011543606 NM_001253891 NP_001240820 NM_032564 NP_115953
Function Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT). {ECO:0000250}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:14521909}; Multi-pass membrane protein {ECO:0000269|PubMed:14521909}. Lipid droplet {ECO:0000250}.
Tissue Specificity Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin. {ECO:0000269|PubMed:11481335, ECO:0000269|PubMed:14521909}.
Top Pathways Fat digestion and absorption, Glycerolipid metabolism

DGAT2 CRISPR/Cas9 KO Plasmid (h) - sc-416229 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DGAT2 HDR Plasmid (h) - sc-416229-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DGAT2 Double Nickase Plasmid (h) - sc-416229-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DGAT2 Double Nickase Plasmid (h2) - sc-416229-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DGAT2 CRISPR Activation Plasmid (h) - sc-416229-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DGAT2 CRISPR Activation Plasmid (h2) - sc-416229-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DGAT2 Lentiviral Activation Particles (h) - sc-416229-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DGAT2 Lentiviral Activation Particles (h2) - sc-416229-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DGAT2 siRNA (h) - sc-45520 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DGAT2 shRNA Plasmid (h) - sc-45520-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DGAT2 shRNA (h) Lentiviral Particles - sc-45520-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU043891 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7167 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7167 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07755 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07755

DGAT2 siRNA (Human) - CRJ3556 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DGAT2 - MBS8213826 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DGAT2 (NM_032564.4) - SHH277353 from Creative biogene

Category siRNA
Species Reactivities Human

Human DGAT2 siRNA - orb274057 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DGAT2 shRNA Plasmid (Human) - CHJ3556 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DGAT2 miRNA 3'UTR clone - MiUTR3H-08873 from Creative biogene

Species Reactivities Human
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