| Gene Symbol |
DGAT2
|
| Entrez Gene |
84649
|
| Alt Symbol |
ARAT, GS1999FULL, HMFN1045
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
diacylglycerol O-acyltransferase 2
|
| Other Description |
acyl-CoA retinol O-fatty-acyltransferase|diacylglycerol O-acyltransferase homolog 2|diacylglycerol O-acyltransferase-like protein 2|diglyceride acyltransferase 2|retinol O-fatty-acyltransferase
|
| Swissprots |
Q8NDB7 Q68CL3 Q96PD7 Q68DJ0 Q9BYE5 Q5U810 A6ND76 Q96BS0
|
| Accessions |
CBF67543 CBF90902 CBU92416 CBV04422 EAW74984 EAW74985 Q96PD7 AB048286 BAB40641 AB073384 BAD38635 AF384161 AAK84176 AI126704 AK074203 AK091870 AL834287 CAD38961 AY358532 AAQ88896 AY780646 AY780647 AAV35727 BC015234 AAH15234 CR749377 CAH18230 DB462004 HQ448288 ADQ32768 XM_011545304 XP_011543606 NM_001253891 NP_001240820 NM_032564 NP_115953
|
| Function |
Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT). {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:14521909}; Multi-pass membrane protein {ECO:0000269|PubMed:14521909}. Lipid droplet {ECO:0000250}.
|
| Tissue Specificity |
Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin. {ECO:0000269|PubMed:11481335, ECO:0000269|PubMed:14521909}.
|
| Top Pathways |
Fat digestion and absorption, Glycerolipid metabolism
|
![Western Blot: DGAT2 Overexpression Lysate (Adult Normal) [NBL1-09845] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DGAT2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2489_DGAT2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09845-img0002.jpg)