| Gene Symbol |
FNDC5
|
| Entrez Gene |
252995
|
| Alt Symbol |
FRCP2, irisin
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
fibronectin type III domain containing 5
|
| Other Description |
fibronectin type III domain-containing protein 5|fibronectin type III repeat-containing protein 2
|
| Swissprots |
D3DPQ6 A6NMC9 Q8NAU1 Q6P6D9 Q7Z676
|
| Accessions |
EAX07499 EAX07500 EAX07501 EAX07502 Q8NAU1 AK092102 BAC03806 BC007548 BC033123 BC062297 AAH62297 BE502835 BX537781 CAD97840 CV815003 DA393478 NM_001171940 NP_001165411 NM_001171941 NP_001165412 NM_153756 NP_715637
|
| Function |
Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue. {ECO:0000269|PubMed:24040023}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:22237023}; Single-pass type I membrane protein {ECO:0000269|PubMed:22237023}. Peroxisome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Imported in peroxisomes through the PEX5 receptor pathway. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen. {ECO:0000269|PubMed:24040023}.
|
