| Gene Symbol | DNAJB11 |
|---|---|
| Entrez Gene | 51726 |
| Alt Symbol | ABBP-2, ABBP2, DJ9, Dj-9, EDJ, ERdj3, ERj3, ERj3p, PRO1080, UNQ537 |
| Species | Human |
| Gene Type | protein-coding |
| Description | DnaJ (Hsp40) homolog, subfamily B, member 11 |
| Other Description | APOBEC1-binding protein 2|DnaJ protein 9|ER-associated DNAJ protein 3|ER-associated Hsp40 co-chaperone|ER-resident protein ERdj3|PWP1-interacting protein 4|dnaJ homolog subfamily B member 11|endoplasmic reticulum DNA J domain-containing protein 3 |
| Swissprots | Q6IAQ8 Q542Y5 Q542Y9 Q96JC6 Q9UBS4 |
| Accessions | CAI72116 EAW78190 Q9UBS4 AB028859 BAA88307 AF228505 AAF61711 AF277317 AAK69110 AI446699 AJ250137 CAB65118 AK075300 BAC11533 AK075430 BAC11617 AK124289 BAG54025 AK301292 BAG62850 AY359043 AAQ89402 BC001144 AAH01144 BC046500 BM754506 BT007063 AAP35712 CR457096 CAG33377 DA058195 DQ890601 ABM92218 DQ893869 ABM84795 NM_016306 NP_057390 |
| Function | Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. {ECO:0000269|PubMed:10827079, ECO:0000269|PubMed:15525676}. |
| Subcellular Location | Endoplasmic reticulum lumen {ECO:0000269|PubMed:10827079, ECO:0000269|PubMed:15195998, ECO:0000269|PubMed:15525676, ECO:0000269|PubMed:15544163}. Note=Associated with the ER membrane in a C-terminally epitope- tagged construct. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:10827079, ECO:0000269|PubMed:11584023, ECO:0000269|PubMed:15525676}. |
| Top Pathways | Protein processing in endoplasmic reticulum |