KCTD11

Gene Symbol	KCTD11
Entrez Gene	147040
Alt Symbol	C17orf36, KCASH1, REN, REN/KCTD11
Species	Human
Gene Type	protein-coding
Description	potassium channel tetramerization domain containing 11
Other Description	BTB/POZ domain-containing protein KCTD11|potassium channel tetramerisation domain containing 11|retinoic acid, EGF, NGF induced gene protein|retinoic acid, EGF, NGF induced gene/potassium channel tetramerization domain containing 11
Swissprots	Q693B1 B3KPE0
Accessions	EAW90208 Q693B1 AK056227 BAG51652 AY646650 AAT75307 BC019929 AAH19929 BC063604 BC103744 BC110598 AAI10599 NM_001002914 NP_001002914
Function	Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock- down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade. {ECO:0000269|PubMed:15249678, ECO:0000269|PubMed:20081843, E
Tissue Specificity	Higher expression in cerebellum than in whole brain and lower expression in medulloblastoma. {ECO:0000269|PubMed:15249678}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KCTD11 full length protein - ab140589 from Abcam Category Protein Source E. coli Species Human

KCTD11 protein (His-DHFR tag) - ab127583 from Abcam Category Protein Source E. coli Species Human

KCTD11 Antibody Blocking Peptide - LS-E27523 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCTD11 Antibody Blocking Peptide - LS-E13184 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCTD11 Antibody Blocking Peptide - LS-E12664 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human KCTD11 Protein - NBP2-23352 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E.coli Species Human

KCTD11 Protein Lysate (APL10930) - APL10930 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

Human KCTD11 protein - orb168688 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E.coli

KCTD11 Blocking Peptide - 33R-1090 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KCTD11 Blocking Peptide - 33R-8026 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KCTD11 protein (His tag) - 80R-2687 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source E.coli

KCTD11 Peptide - AC21-2346-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

KCTD11 (1-232, His-tag) - AR50807PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

KCTD11 (1-232, His-tag) - AR50807PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

KCTD11, 1-232aa, Human, His tag, E.coli - 01-P1983 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

KCTD11 Peptide - 42-417P from ProSci Category Peptide Species Human

KCTD11 fusion protein - Ag15973 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

KCTD11 fusion protein - Ag15586 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human KCTD11, His-tagged - KCTD11-7539H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human KCTD11, His-tagged - KCTD11-290H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human BTB/POZ domain-containing protein KCTD11(KCTD11) - CSB-YP737961HU CSB-EP737961HU CSB-BP737961HU CSB-MP737961HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

KCTD11, 1-232aa, Human, His tag, E.coli (Denatured) - ATGP1983 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 10 µg, 50 µg, 250 µg Species Human

Potassium Channel Tetramerisation Domain Containing 11 Protein (Recombinant) - abx262586 from Abbexa Category Protein

KCTD11 - TP305782 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Potassium Channel Tetramerisation Domain Containing 11, Recombinant Protein - MBS145683 from MyBioSource Category Protein Prices $140.00, $205.00, $5,015.00 Sizes 2 µg, 10 µg, 1 mg Source E Coli

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