KCTD11

Gene Symbol	KCTD11
Entrez Gene	147040
Alt Symbol	C17orf36, KCASH1, REN, REN/KCTD11
Species	Human
Gene Type	protein-coding
Description	potassium channel tetramerization domain containing 11
Other Description	BTB/POZ domain-containing protein KCTD11\|potassium channel tetramerisation domain containing 11\|retinoic acid, EGF, NGF induced gene protein\|retinoic acid, EGF, NGF induced gene/potassium channel tetramerization domain containing 11
Swissprots	Q693B1 B3KPE0
Accessions	EAW90208 Q693B1 AK056227 BAG51652 AY646650 AAT75307 BC019929 AAH19929 BC063604 BC103744 BC110598 AAI10599 NM_001002914 NP_001002914
Function	Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock- down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade. {ECO:0000269\|PubMed:15249678, ECO:0000269\|PubMed:20081843, E
Tissue Specificity	Higher expression in cerebellum than in whole brain and lower expression in medulloblastoma. {ECO:0000269\|PubMed:15249678}.

KCTD11 (E-16) - sc-107659 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

KCTD11 (H-167) - sc-366544 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

KCTD11 (H-167): sc-366544. Western blot analysis of KCTD11 expression in IMR-32 whole cell lysate.

KCTD11 (H-25) - sc-133705 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

KCTD11 (H-25): sc-133705. Western blot analysis of KCTD11 expression in Hep G2 whole cell lysate.

Anti-KCTD11 antibody - ab33059 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-KCTD11 antibody (ab33059) at 1.25 µg/ml + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti Rabbit IgG at 1/50000 dilution

Anti-KCTD11 Antibody (aa167-178) - LS-C139708 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-KCTD11 Antibody (aa61-110) - LS-C30637 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-KCTD11 Antibody (aa41-90) - LS-C31800 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

KCTD11 Antibody - NBP1-80109 from Novus Biologicals

Prices	$139.00, $299.00
Sizes	20 µl, 100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: KCTD11 Antibody [NBP1-80109] - Jurkat cell lysate, concentration 1.25ug/ml.

KCTD11 Antibody - NBP1-72049 from Novus Biologicals

Prices	$299.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

KCTD11 Antibody - NBP1-80211 from Novus Biologicals

Prices	$299.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: KCTD11 Antibody [NBP1-80211] - HepG2 cell lysate, concentration 1.25ug/ml.

KCTD11 Polyclonal Antibody - bs-9637R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-KCTD11 antibody produced in rabbit - HPA052035 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-KCTD11: <B>Cat. No. HPA052035</B>: Immunohistochemical staining of human cerebellum shows moderate nuclear positivity in Purkinje cells and cells in molecular layer.

Anti-KCTD11 antibody produced in goat - SAB2501865 from Sigma-Aldrich

Prices	$376.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-KCTD11: <B>Cat. No. SAB2501865</B>: HEK293 lysate (10 μg protein in RIPA buffer). <BR/><B>Lanes</B><BR/>A. Over-expressing Human KCTD11 with DYKDDDDK tag probed with <B>SAB2501865</B> (1.0 μg/ml)<BR/>B. Mock-transfected HEK293 probed with <B>SAB2501865</B> (1 mg/mL)<BR/>C. Overexpressing Human KCTD11 with DYKDDDDK tag probed with Anti-DYKDDDDK Tag (1/5000).

Anti-KCTD11 (AB2) antibody produced in rabbit - AV35623 from Sigma-Aldrich

Prices	$267.50
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Cell Type: Jurkat (<B>Cat. No. AV35623</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1.25 μg/mL in cell type Jurkat

KCTD11 antibody - N-terminal region (ARP35623_T100) - ARP35623_T100 from Aviva Systems Biology

Prices	$229.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

KCTD11 antibody - N-terminal region (ARP36786_T100) - ARP36786_T100 from Aviva Systems Biology

Prices	$229.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

KCTD11-Antibody-internal-region - AF3376a from Abgent, a WuXi AppTec company

Prices	$335.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

HEK293 lysate (10ug protein in RIPA buffer) overexpressing Human KCTD11 with DYKDDDDK tag probed with AF3376a (1.0ug/ml) in Lane A and probed with anti-DYKDDDDK Tag (1/5000) in lane C. Mock-transfected HEK293 probed with AF3376a (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.

KCTD11 antibody, N-term - GTX47451 from GeneTex

Prices	$319.00
Sizes	100 μg
Host	Rabbit
Clonality	Polyclonal

KCTD11 antibody, N-term - GTX47532 from GeneTex

Prices	$319.00
Sizes	100 μg
Host	Rabbit
Clonality	Polyclonal

KCTD11 antibody - orb22520 from Biorbyt

Prices	$408.00
Sizes	100 μg
Host	Goat
Clonality	Polyclonal

Western blot analysis of HEK293 lysate (1.0ug/ml) using KCTD11 antibody

KCTD11 Antibody (OAEB02498) - OAEB02498 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

KCTD11 antibody - 70R-1493 from Fitzgerald

Prices	$275.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti -KCTD11 (BTB/POZ Domain-containing Protein KCTD11, C17orf36, REN) - K0091-11 from USBiological Life Science

Host	Goat
Clonality	Polyclonal

Anti -KCTD11 (BTB/POZ Domain-containing Protein KCTD11, C17orf36, REN) (AP) - K0091-11-AP from USBiological Life Science

Host	Goat
Clonality	Polyclonal

Anti -KCTD11 (BTB/POZ Domain-containing Protein KCTD11, C17orf36, REN) (APC) - K0091-11-APC from USBiological Life Science

Host	Goat
Clonality	Polyclonal

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