KCTD11

Gene Symbol KCTD11
Entrez Gene 147040
Alt Symbol C17orf36, KCASH1, REN, REN/KCTD11
Species Human
Gene Type protein-coding
Description potassium channel tetramerization domain containing 11
Other Description BTB/POZ domain-containing protein KCTD11|potassium channel tetramerisation domain containing 11|retinoic acid, EGF, NGF induced gene protein|retinoic acid, EGF, NGF induced gene/potassium channel tetramerization domain containing 11
Swissprots Q693B1 B3KPE0
Accessions EAW90208 Q693B1 AK056227 BAG51652 AY646650 AAT75307 BC019929 AAH19929 BC063604 BC103744 BC110598 AAI10599 NM_001002914 NP_001002914
Function Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock- down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade. {ECO:0000269|PubMed:15249678, ECO:0000269|PubMed:20081843, E
Tissue Specificity Higher expression in cerebellum than in whole brain and lower expression in medulloblastoma. {ECO:0000269|PubMed:15249678}.

KCTD11 CRISPR/Cas9 KO Plasmid (h) - sc-414602 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCTD11 HDR Plasmid (h) - sc-414602-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCTD11 Double Nickase Plasmid (h) - sc-414602-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCTD11 Double Nickase Plasmid (h2) - sc-414602-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCTD11 CRISPR Activation Plasmid (h) - sc-414602-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCTD11 CRISPR Activation Plasmid (h2) - sc-414602-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCTD11 Lentiviral Activation Particles (h) - sc-414602-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCTD11 Lentiviral Activation Particles (h2) - sc-414602-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCTD11 siRNA (h) - sc-93577 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KCTD11 shRNA Plasmid (h) - sc-93577-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KCTD11 shRNA (h) Lentiviral Particles - sc-93577-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU228801 from Sigma-Aldrich

Category siRNA
Prices $140.00, $140.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11001 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11001 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

KCTD11 siRNA (Human) - CRJ5508 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

KCTD11 RNAi - H00147040-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human KCTD11 (NM_001002914.2) - SHH323843 from Creative biogene

Category siRNA
Species Reactivities Human

KCTD11 shRNA Plasmid (Human) - CHJ5508 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

KCTD11 miRNA 3'UTR clone - MiUTR1H-05173 from Creative biogene

Species Reactivities Human
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