S1PR5

Gene Symbol S1PR5
Entrez Gene 53637
Alt Symbol EDG8, Edg-8, S1P5, SPPR-1, SPPR-2
Species Human
Gene Type protein-coding
Description sphingosine-1-phosphate receptor 5
Other Description S1P receptor 5|S1P receptor Edg-8|endothelial differentiation G-protein-coupled receptor 8|endothelial differentiation, sphingolipid G-protein-coupled receptor, 8|sphingosine 1-phosphate receptor 5|sphingosine 1-phosphate receptor EDG8|sphingosine 1-phosphate receptor Edg-8
Swissprots Q6NW11 Q9H228
Accessions AAG38113 AAP20653 BAB89315 CAF85890 EAW84113 EAW84114 EAW84115 Q9H228 AF088014 AF331840 AAL57041 AF331841 AAL57042 AF331842 AAL57043 AK074661 BAC11119 AK094880 BC034703 AAH34703 BC067781 AAH67781 DA747912 DA866378 DB013424 DQ891290 ABM82216 DQ893341 ABM84267 DQ894474 ABM85400 DQ896661 ABM87660 NM_001166215 NP_001159687 NM_030760 NP_110387
Function Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. {ECO:0000250}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes. {ECO:0000269|PubMed:11705398, ECO:0000269|PubMed:12234605, ECO:0000269|PubMed:12427546}.
Top Pathways Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction

EDG-8 (H-88) - sc-25493 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
EDG-8 (H-88): sc-25493. Western blot analysis of EDG-8 expression in non-transfected 293T: sc-117752 (A), human EDG-8 transfected 293T: sc-113850 (B) and HeLa (C) whole cell lysates.

EDG-8 (G-13) - sc-16093 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EDG-8 (G-13): sc-16093. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic and membrane staining of hepatocytes.

EDG-8 (C-20) - sc-16094 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-EDG8 antibody - ab92994 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-EDG8 antibody (ab92994) at 1 µg/mlLane 1 : Brain: corpus callosum (Human) Whole Cell Lysate - Alzheimer (ab30027)Lane 2 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466)Lane 3 : Spleen (Human) Tissue Lysate - adult normal tissue (ab29699)Lane 4 : Lung (Human) Tissue Lysate Lane 5 : U937 (Human leukemic monocyte lymphoma cell line) Whole Cell Lysate Lane 6 : MOLT4 (Human acute lymphoblastic leukemia cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal Secondary Antibody to Rabbit IgG - H&L (HRP), pre-adsorbed at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-EDG8 antibody - ab167049 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-EDG8 antibody - ab89677 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EDG8 antibody - Aminoterminal end - ab60039 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab60039 at 1/50 dilution staining EDG8 in Human hepatocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. A peroxidase-conjugated secondary antibody was used, followed by AEC staining.

Anti-EDG8 antibody - C-terminal - ab180216 from Abcam

Prices $357.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
All lanes : Anti-EDG8 antibody - C-terminal (ab180216) at 1 µg/mlLane 1 : Human Frontal Cortex lysate in RIPA bufferLane 2 : Amygdala lysate in RIPA bufferLysates/proteins at 35 µg per lane.developed using the ECL technique

Anti-S1PR5 / EDG8 / S1P5 Antibody (APC) - LS-C132176 from LifeSpan Bioscience

Prices $590.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal

Anti-S1PR5 / EDG8 / S1P5 Antibody (PE) - LS-C132177 from LifeSpan Bioscience

Prices $530.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal

Anti-S1PR5 / EDG8 / S1P5 Antibody (aa218-247, AP) - LS-C217384 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-S1PR5 / EDG8 / S1P5 Antibody (aa218-247, Biotin) - LS-C217385 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-S1PR5 / EDG8 / S1P5 Antibody (aa218-247, APC) - LS-C217386 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-S1PR5 / EDG8 / S1P5 Antibody (aa218-247, FITC) - LS-C217387 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-S1PR5 / EDG8 / S1P5 Antibody (C-Terminus) - LS-C26593 from LifeSpan Bioscience

Prices $570.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of anti-EDG-8 CT antibody on RH7777 cell lysates transfected with full length human EDG8 (1) and blocked with blocking peptide (2) using Pierce Femto Signal substrate.

Anti-S1PR5 / EDG8 / S1P5 Antibody (aa218-247, Azide-free, HRP) - LS-C217388 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-S1PR5 / EDG8 / S1P5 Antibody (N-Terminus) - LS-C31935 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
S1PR5 / EDG8 antibody LS-C31935 was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.

Anti-S1PR5 / EDG8 / S1P5 Antibody (aa218-247, PE) - LS-C217389 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-S1PR5 / EDG8 / S1P5 Antibody (aa218-247) - LS-C330091 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-S1PR5 / EDG8 / S1P5 Antibody (aa335-384) - LS-C198898 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain tissue, using EDG8 Antibody. The sample on the right was incubated with synthetic peptide.

Anti-S1PR5 / EDG8 / S1P5 Antibody (N-Terminus) - LS-C40395 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
S1PR5 / EDG8 antibody LS-C40395 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-S1PR5 / EDG8 / S1P5 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A316 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-S1PR5 / EDG8 antibody LS-A316 IHC of human brain, neuron and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-S1PR5 / EDG8 / S1P5 Antibody (aa219-247) - LS-C162837 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
S1PR5 Antibody western blot of A549 cell line lysates (35 ug/lane). The S1PR5 antibody detected the S1PR5 protein (arrow).

Anti-S1PR5 / EDG8 / S1P5 Antibody IHC-plus™ - LS-B515 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-S1PR5 / EDG8 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B515 concentration 5 ug/ml.

Anti-S1PR5 / EDG8 / S1P5 Antibody (N-Terminus) IHC-plus™ - LS-A3802 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-S1PR5 / EDG8 antibody LS-A3802 IHC of rat brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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