S1PR5

Gene Symbol	S1PR5
Entrez Gene	53637
Alt Symbol	EDG8, Edg-8, S1P5, SPPR-1, SPPR-2
Species	Human
Gene Type	protein-coding
Description	sphingosine-1-phosphate receptor 5
Other Description	S1P receptor 5|S1P receptor Edg-8|endothelial differentiation G-protein-coupled receptor 8|endothelial differentiation, sphingolipid G-protein-coupled receptor, 8|sphingosine 1-phosphate receptor 5|sphingosine 1-phosphate receptor EDG8|sphingosine 1-phosphate receptor Edg-8
Swissprots	Q6NW11 Q9H228
Accessions	AAG38113 AAP20653 BAB89315 CAF85890 EAW84113 EAW84114 EAW84115 Q9H228 AF088014 AF331840 AAL57041 AF331841 AAL57042 AF331842 AAL57043 AK074661 BAC11119 AK094880 BC034703 AAH34703 BC067781 AAH67781 DA747912 DA866378 DB013424 DQ891290 ABM82216 DQ893341 ABM84267 DQ894474 ABM85400 DQ896661 ABM87660 NM_001166215 NP_001159687 NM_030760 NP_110387
Function	Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. {ECO:0000250}.
Subcellular Location	Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes. {ECO:0000269|PubMed:11705398, ECO:0000269|PubMed:12234605, ECO:0000269|PubMed:12427546}.
Top Pathways	Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EDG8 full length protein - ab132112 from Abcam Category Protein Source Wheat germ Species Human

Human EDG8 peptide - ab103906 from Abcam Category Peptide

S1PR5 / EDG8 / S1P5 Antibody Blocking Peptide - LS-E3257 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

S1PR5 / EDG8 / S1P5 Antibody Blocking Peptide - LS-E28817 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

S1PR5 / EDG8 / S1P5 Antibody Blocking Peptide - LS-E28695 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

S1PR5 / EDG8 / S1P5 Antibody Blocking Peptide - LS-E15711 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human S1P5/EDG-8 Protein - H00053637-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human S1P5/EDG-8 Protein - H00053637-G01 from Novus Biologicals Category Protein Prices $569.00 Sizes 10 µg Source Wheat Germ Species Human

S1PR5-Antibody-Center-Blocking-Peptide - BP14409c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EDG8 Blocking Peptide - 33R-5958 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EDG8 Blocking Peptide - 33R-5959 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EDG8 Peptide - AC21-2820-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

EDG8 / S1P5 - H00053637-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 2 µg Species Human

EDG8 / S1P5 - H00053637-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EDG8 / S1P5 - H00053637-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

S1PR5 fusion protein - Ag4928 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human S1PR5, GST-tagged - S1PR5-2496H from Creative Biomart Category Protein Source E.coli Species Human

ChemiSCREEN™ Membrane Preparation Recombinant Human S1P 5 Lysophospholipid Receptor - HTS193M from EMD Millipore Prices $596.00 Sizes 200 units Species Human

S1PR5 Peptide (OEEG01118) - OEEG01118 from Aviva Systems Biology Category Peptide Prices $150.00 Sizes 50 µg

EDG8/SPPR1, Peptide - MBS428354 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Pig, Bovine

S1P5/EDG-8 Recombinant Protein Antigen - NBP1-84902PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

EDG8-Antibody-N-term-Blocking-Peptide - BP6144a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

S1PR5 Peptide, Human - M34GP13741H from Creative Peptides Category Peptide Source Synthetic. Species Human

Sphingosine 1-phosphate receptor 5 (S1PR5), Recombinant Protein - MBS7099183 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Sphingosine 1-phosphate receptor 5 (S1PR5), Recombinant Protein - MBS7029214 from MyBioSource Category Protein Prices $1,205.00, $2,190.00, $3,395.00 Sizes 10 µg, 50 µg, 100 µg Source E Coli Species Human

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