| Gene Symbol |
S1PR5
|
| Entrez Gene |
53637
|
| Alt Symbol |
EDG8, Edg-8, S1P5, SPPR-1, SPPR-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sphingosine-1-phosphate receptor 5
|
| Other Description |
S1P receptor 5|S1P receptor Edg-8|endothelial differentiation G-protein-coupled receptor 8|endothelial differentiation, sphingolipid G-protein-coupled receptor, 8|sphingosine 1-phosphate receptor 5|sphingosine 1-phosphate receptor EDG8|sphingosine 1-phosphate receptor Edg-8
|
| Swissprots |
Q6NW11 Q9H228
|
| Accessions |
AAG38113 AAP20653 BAB89315 CAF85890 EAW84113 EAW84114 EAW84115 Q9H228 AF088014 AF331840 AAL57041 AF331841 AAL57042 AF331842 AAL57043 AK074661 BAC11119 AK094880 BC034703 AAH34703 BC067781 AAH67781 DA747912 DA866378 DB013424 DQ891290 ABM82216 DQ893341 ABM84267 DQ894474 ABM85400 DQ896661 ABM87660 NM_001166215 NP_001159687 NM_030760 NP_110387
|
| Function |
Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes. {ECO:0000269|PubMed:11705398, ECO:0000269|PubMed:12234605, ECO:0000269|PubMed:12427546}.
|
| Top Pathways |
Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction
|