| Gene Symbol |
CCNF
|
| Entrez Gene |
899
|
| Alt Symbol |
FBX1, FBXO1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cyclin F
|
| Other Description |
F-box only protein 1|G2/mitotic-specific cyclin-F|cyclin-F
|
| Swissprots |
P41002 Q96EG9 B2R8H3
|
| Accessions |
EAW85510 P41002 AB208829 BAD92066 AK313371 BAG36170 BC012349 AAH12349 DA960397 DB523776 DQ890775 ABM81701 U17105 AAB60342 Z36714 CAA85308 NM_001761 NP_001752
|
| Function |
Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. {ECO:0000269|PubMed:20596027}.
|
| Subcellular Location |
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:7813445}.
|
![Western Blot: Cyclin F Overexpression Lysate (Adult Normal) [NBL1-08879] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Cyclin F.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/12366_Cyclin%2520F%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-08879-img0002.jpg)