GEMIN6

Gene Symbol GEMIN6
Entrez Gene 79833
Alt Symbol -
Species Human
Gene Type protein-coding
Description gem (nuclear organelle) associated protein 6
Other Description SIP2|gem-associated protein 6|gemin 6|gemin-6
Swissprots Q8WXD5 B2RDP8 Q53SI5 Q8WVB4 Q9H5G6
Accessions AAY24255 EAX00360 EAX00361 Q8WXD5 AF453443 AAL48292 AK027112 BAB15660 AK315627 BAG37995 BC018195 AAH18195 BC029584 BM471707 XM_005264568 XP_005264625 NM_024775 NP_079051
Function The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. {ECO:0000269|PubMed:11748230, ECO:0000269|PubMed:18984161}.
Subcellular Location Nucleus, nucleoplasm {ECO:0000269|PubMed:11748230}. Nucleus, gem {ECO:0000269|PubMed:11748230}. Cytoplasm {ECO:0000269|PubMed:11748230}. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
Top Pathways RNA transport

Gemin6 (20H8) - sc-130667 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Gemin6 (C-20) - sc-21443 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Gemin6 (FL-167) - sc-367218 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Gemin6 (FL-167): sc-367218. Western blot analysis of Gemin6 expression in SW-13 whole cell lysate.

Anti-Gemin 6 antibody - ab88290 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Gemin 6 antibody (ab88290) at 1 µg/ml + HeLa cell lysate with Gemin 6 expression at 50 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution

Anti-Gemin 6 antibody - ab189581 from Abcam

Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Gemin 6 antibody (ab189581) at 1/1000 dilution (incubated for 2 hours at room temperature)Lanes 2 - 4 : Anti-Gemin 6 antibody (ab189581) at 1/1000 dilution (incubated for 2 hours at room temperature)Lane 1 : Mouse brain lysateLane 2 : Mouse thymus lysateLane 3 : HeLa cell lysateLane 4 : Jurkat cell lysate

Anti-Gemin 6 antibody - ab104488 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Gemin 6 antibody (ab104488) at 1 µg/ml + Human stomach tissue lysate at 50 µg

Anti-Gemin 6 antibody - ab57727 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57727 Gemin 6 antibody at 1ug/ml.

Anti-Gemin 6 antibody - ab118700 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Gemin 6 antibody (ab118700) at 1 µg/ml + Human fetal lung lysate at 10 µg

Anti-Gemin 6 antibody - C-terminal - ab189596 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-Gemin 6 antibody - C-terminal (ab189596) at 1/1000 dilutionLane 1 : HeLa total cell extractLane 2 : Jurkat total cell extract

Anti-GEMIN6 / Gemin-6 Antibody - LS-C310471 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GEMIN6 / Gemin-6 Antibody (aa62-111) - LS-C145723 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GEMIN6 antibody LS-C145723 Western blot of Fetal Lung lysate. Antibody concentration 1 ug/ml.

Anti-GEMIN6 / Gemin-6 Antibody - LS-C307672 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-GEMIN6 / Gemin-6 Antibody - LS-C307675 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

GEMIN6 Antibody - H00079833-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: GEMIN6 Antibody [H00079833-B01P] - Analysis of GEMIN6 expression in HeLa.

GEMIN6 Antibody - NBP1-82075 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: GEMIN6 Antibody [NBP1-82075] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

GEMIN6 Antibody - H00079833-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: GEMIN6 Antibody [H00079833-D01P] - Analysis of GEMIN6 expression in human stomach.

GEMIN6 Antibody (3D2) - H00079833-M08 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D2
ELISA: GEMIN6 Antibody (3D2) [H00079833-M08] - Detection limit for recombinant GST tagged GEMIN6 is approximately 0.3ng/ml as a capture antibody.

Gemin 6 Polyclonal Antibody - bs-13333R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Gemin 6 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13333R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Gemin 6 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-13333R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Gemin 6 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-13333R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Gemin 6 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-13333R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Gemin 6 Polyclonal Antibody, Cy3 Conjugated - bs-13333R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Gemin 6 Polyclonal Antibody, Cy5 Conjugated - bs-13333R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Gemin 6 Polyclonal Antibody, Cy5.5 Conjugated - bs-13333R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Search more