GEMIN6

Gene Symbol	GEMIN6
Entrez Gene	79833
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	gem (nuclear organelle) associated protein 6
Other Description	SIP2|gem-associated protein 6|gemin 6|gemin-6
Swissprots	Q8WXD5 B2RDP8 Q53SI5 Q8WVB4 Q9H5G6
Accessions	AAY24255 EAX00360 EAX00361 Q8WXD5 AF453443 AAL48292 AK027112 BAB15660 AK315627 BAG37995 BC018195 AAH18195 BC029584 BM471707 XM_005264568 XP_005264625 NM_024775 NP_079051
Function	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. {ECO:0000269|PubMed:11748230, ECO:0000269|PubMed:18984161}.
Subcellular Location	Nucleus, nucleoplasm {ECO:0000269|PubMed:11748230}. Nucleus, gem {ECO:0000269|PubMed:11748230}. Cytoplasm {ECO:0000269|PubMed:11748230}. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Gemin 6 full length protein - ab140556 from Abcam Category Protein Source E. coli Species Human

GEMIN6 / Gemin-6 Antibody Blocking Peptide - LS-E22687 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GEMIN6 Recombinant Protein - H00079833-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human GEMIN6 Protein - NBP2-23073 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E.coli Species Human

GEMIN6 Protein - GTX116846-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

Human GEMIN6 protein - orb168387 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E.coli

GEMIN6 protein (His tag) - 80R-2708 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source E.coli

Gemin-6 (1-167, His-tag) - AR50828PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

Gemin-6 (1-167, His-tag) - AR50828PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

Gemin-6 - H00079833-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Gemin-6 - H00079833-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

GEMIN6, 1-167aa, Human, His tag, E.coli - 01-P2004 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

GEMIN6 fusion protein - Ag2954 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

GEMIN6 Human - PRPS-1401 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source E.coli. Species Human

Recombinant Human GEMIN6, His-tagged - GEMIN6-7560H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human GEMIN6, GST-tagged - GEMIN6-13224H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Gem-associated protein 6(GEMIN6) - CSB-YP823902HU CSB-EP823902HU CSB-BP823902HU CSB-MP823902HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

GEMIN6, 1-167aa, Human, His tag, E.coli - ATGP2004 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 10 µg, 50 µg, 250 µg Species Human

Gemin-6 - TP302296 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

GEMIN6 Recombinant Protein Antigen - NBP1-82075PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

GEMIN6 Peptide, Human - M34GP06207H from Creative Peptides Category Peptide Source Synthetic. Species Human

Gem-Associated Protein 6, Recombinant Protein - MBS146087 from MyBioSource Category Protein Prices $140.00, $205.00, $5,015.00 Sizes 2 µg, 10 µg, 1 mg Source E Coli

Gem-associated protein 6 (GEMIN6), Recombinant Protein - MBS1309815 from MyBioSource Category Protein Prices $910.00, $910.00, $1,135.00, $1,135.00, $1,350.00, $1,350.00, $1,805.00, $1,805.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

GEMIN6, Recombinant Protein - MBS205257 from MyBioSource Category Protein Prices $375.00, $925.00 Sizes 50 µg, 250 µg Source E Coli Species Human

DGCR6L - PAT-82084-1 from Nordic BioSite Category Protein Species Human

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