| Gene Symbol | GEMIN6 |
|---|---|
| Entrez Gene | 79833 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | gem (nuclear organelle) associated protein 6 |
| Other Description | SIP2|gem-associated protein 6|gemin 6|gemin-6 |
| Swissprots | Q8WXD5 B2RDP8 Q53SI5 Q8WVB4 Q9H5G6 |
| Accessions | AAY24255 EAX00360 EAX00361 Q8WXD5 AF453443 AAL48292 AK027112 BAB15660 AK315627 BAG37995 BC018195 AAH18195 BC029584 BM471707 XM_005264568 XP_005264625 NM_024775 NP_079051 |
| Function | The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. {ECO:0000269|PubMed:11748230, ECO:0000269|PubMed:18984161}. |
| Subcellular Location | Nucleus, nucleoplasm {ECO:0000269|PubMed:11748230}. Nucleus, gem {ECO:0000269|PubMed:11748230}. Cytoplasm {ECO:0000269|PubMed:11748230}. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm. |
| Top Pathways | RNA transport |
Gemin6 CRISPR/Cas9 KO Plasmid (h) - sc-407093 from Santa Cruz Biotechnology
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Gemin6 HDR Plasmid (h) - sc-407093-HDR from Santa Cruz Biotechnology
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Gemin6 Double Nickase Plasmid (h) - sc-407093-NIC from Santa Cruz Biotechnology
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Gemin6 Double Nickase Plasmid (h2) - sc-407093-NIC-2 from Santa Cruz Biotechnology
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Gemin6 CRISPR Activation Plasmid (h) - sc-407093-ACT from Santa Cruz Biotechnology
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Gemin6 CRISPR Activation Plasmid (h2) - sc-407093-ACT-2 from Santa Cruz Biotechnology
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Gemin6 Lentiviral Activation Particles (h) - sc-407093-LAC from Santa Cruz Biotechnology
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Gemin6 Lentiviral Activation Particles (h2) - sc-407093-LAC-2 from Santa Cruz Biotechnology
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Gemin6 siRNA (h) - sc-42132 from Santa Cruz Biotechnology
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Gemin6 shRNA Plasmid (h) - sc-42132-SH from Santa Cruz Biotechnology
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Gemin6 shRNA (h) Lentiviral Particles - sc-42132-V from Santa Cruz Biotechnology
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GEMIN6 RNAi - H00079833-R01 from Novus Biologicals
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MISSION® esiRNA - EHU027681 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9231 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9231 from Sigma-Aldrich
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GEMIN6 siRNA (Human) - CRJ2598 from Cohesion Biosciences
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GEMIN6 - MBS8207185 from MyBioSource
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shRNA set against Human GEMIN6 (NM_024775.9) - SHH300486 from Creative biogene
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shRNA set against Human GEMIN6(NM_024775.9) - SHH082037 from Creative biogene
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GEMIN6 shRNA Plasmid (Human) - CHJ2598 from Cohesion Biosciences
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GEMIN6 miRNA 3'UTR clone - MiUTR1H-04007 from Creative biogene
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