| Gene Symbol |
GEMIN6
|
| Entrez Gene |
79833
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
gem (nuclear organelle) associated protein 6
|
| Other Description |
SIP2|gem-associated protein 6|gemin 6|gemin-6
|
| Swissprots |
Q8WXD5 B2RDP8 Q53SI5 Q8WVB4 Q9H5G6
|
| Accessions |
AAY24255 EAX00360 EAX00361 Q8WXD5 AF453443 AAL48292 AK027112 BAB15660 AK315627 BAG37995 BC018195 AAH18195 BC029584 BM471707 XM_005264568 XP_005264625 NM_024775 NP_079051
|
| Function |
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. {ECO:0000269|PubMed:11748230, ECO:0000269|PubMed:18984161}.
|
| Subcellular Location |
Nucleus, nucleoplasm {ECO:0000269|PubMed:11748230}. Nucleus, gem {ECO:0000269|PubMed:11748230}. Cytoplasm {ECO:0000269|PubMed:11748230}. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
|
| Top Pathways |
RNA transport
|