CD163

Gene Symbol	CD163
Entrez Gene	9332
Alt Symbol	M130, MM130
Species	Human
Gene Type	protein-coding
Description	CD163 molecule
Other Description	hemoglobin scavenger receptor|macrophage-associated antigen|scavenger receptor cysteine-rich type 1 protein M130
Swissprots	Q07900 Q07898 Q07899 Q07901 Q86VB7 Q2VLH7 C9JIG2
Accessions	CAB45233 EAW88662 EAW88663 EAW88664 EAW88665 EAW88666 Q86VB7 AA962842 AI128043 AI129762 AK226017 BC051281 AAH51281 DA619387 DB291765 DQ058615 AAY99762 Z22968 CAA80541 Z22969 CAA80542 Z22970 CAA80543 Z22971 CAA80544 XM_005253528 XP_005253585 XM_005253529 XP_005253586 NM_004244 NP_004235 NM_203416 NP_981961
Function	Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
Subcellular Location	Soluble CD163: Secreted.
Tissue Specificity	Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood. {ECO:0000269|PubMed:10577520, ECO:0000269|PubMed:11196644, ECO:0000269|PubMed:16434690}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CD163 (M130) Human ELISA Kit - ab155428 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 30 pg/ml Range 0.032 ng/ml - 8 ng/ml

Mouse CD163 ELISA Kit (Sandwich ELISA) - LS-F2855 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 20 pg/ml Range 32.77-3200 pg/ml

Human CD163 ELISA Kit (Sandwich ELISA) - LS-F2644 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 150 pg/ml Range 32.77-3200 pg/ml

Human CD163 ELISA Kit (Sandwich ELISA) - LS-F47 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 32.77 pg/ml Range 32.77-3200 pg/ml

Human CD163 ELISA Kit (Sandwich ELISA) - LS-F687 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 32.77-3200 pg/ml

Mouse CD163 ELISA Kit (Sandwich ELISA) - LS-F9079 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 31.25 pg/ml Range 32.77-3200 pg/ml

Rat CD163 ELISA Kit (Sandwich ELISA) - LS-F9679 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 6.9 pg/ml Range 32.77-3200 pg/ml

Human CD163 ELISA Kit - RAB0082 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

Human CD163 Quantikine ELISA Kit - DC1630 from R&D Systems Category ELISA Kit Prices $509.00 Sizes 1 kit Sensitivity 0.613 ng/mL Range 1.6 - 100 ng/mL (Cell Culture Supernates, Serum, Heparin Plasma)

Human CD163 DuoSet ELISA - DY1607 from R&D Systems Category ELISA Kit Prices $249.00, $649.00 Sizes 1 kit (for 5 Plates), 1 kit (for 15 Plates) Range 156.00 - 10,000 pg/mL

Mouse CD163 DuoSet ELISA - DY7435 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 0.312 - 20 ng/mL

Quantikine Immunoassay Control Set 903 for Human CD163 - QC61 from R&D Systems Category ELISA Kit Prices $125.00 Sizes 1 each

Human CD163 DuoSet, 5 Plate - DY1607-05 from R&D Systems Category ELISA Kit

CD163 ELISA Kit (Human) : 96 Wells (OKAG00207) - OKAG00207 from Aviva Systems Biology Category ELISA Kit Prices $390.00 Sizes 96 wells Sensitivity 157 pg/mL Range 157-1,0000 pg/mL

Human CD163 ELISA Kit - orb219284 from Biorbyt Category ELISA Kit Prices $706.00 Sizes 96 test Sensitivity 150 pg/ml Range 1560 pg/ml-100000 pg/ml

Human CD163 ELISA Kit - abx056070 from Abbexa Category ELISA Kit

Soluable Cluster of Differentiation 163, sCD163, Human, ELISA Kit - E-EL-H0036 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.938 Range 1.563-100ng/mL

CD163, Human, ELISA Kit - PB-0715 from ARP American Research Products Category ELISA Kit Prices $418.00 Sizes 96 t Sensitivity < 150 pg/ml Range 1.56ng/ml-100ng/ml

Scavenger receptor cysteine-rich type 1 protein M130, CD163, Human, ELISA Kit - E1726h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 0.312-20 ng/mL

Cluster of Differentiation 163, CD163, Rabbit, ELISA Kit - E-EL-RB1982 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cluster of Differentiation 163, CD163, Chicken, ELISA Kit - E-EL-Ch1771 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Cluster of Differentiation 163, CD163, Porcine, ELISA Kit - E-EL-P1224 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.469 Range 0.781-50ng/mL

Cluster of Differentiation 163, CD163, Guinea Pig, ELISA Kit - E-EL-GP0197 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Cluster of Differentiation 163, CD163, Monkey, ELISA Kit - E-EL-MK0788 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human CD163 ELISA - ELH-CD163 from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 30 pg/ml Range 30 pg/ml - 8000 pg/ml

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