CD163

Gene Symbol	CD163
Entrez Gene	9332
Alt Symbol	M130, MM130
Species	Human
Gene Type	protein-coding
Description	CD163 molecule
Other Description	hemoglobin scavenger receptor|macrophage-associated antigen|scavenger receptor cysteine-rich type 1 protein M130
Swissprots	Q07900 Q07898 Q07899 Q07901 Q86VB7 Q2VLH7 C9JIG2
Accessions	CAB45233 EAW88662 EAW88663 EAW88664 EAW88665 EAW88666 Q86VB7 AA962842 AI128043 AI129762 AK226017 BC051281 AAH51281 DA619387 DB291765 DQ058615 AAY99762 Z22968 CAA80541 Z22969 CAA80542 Z22970 CAA80543 Z22971 CAA80544 XM_005253528 XP_005253585 XM_005253529 XP_005253586 NM_004244 NP_004235 NM_203416 NP_981961
Function	Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
Subcellular Location	Soluble CD163: Secreted.
Tissue Specificity	Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood. {ECO:0000269|PubMed:10577520, ECO:0000269|PubMed:11196644, ECO:0000269|PubMed:16434690}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CD163 protein fragment - ab112384 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human CD163 protein fragment - ab117700 from Abcam Category Protein Prices $188.00 Sizes 10 µg Source E. coli Species Human

CD163 Antibody Blocking Peptide - LS-E8869 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CD163 Protein - H00009332-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CD163-Antibody-N-term-Blocking-Peptide - BP7330a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human CD163, CF - 1607-CD-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gly41-Ser1045, with a C-terminal 10-His tag

Porcine CD163 protein - orb81017 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 10 μg, 50 μg Species Pig

CD163 - H00009332-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD163 - H00009332-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CD163 fusion protein - ag10029 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human CD163, His-tagged - CD163-4272H from Creative Biomart Category Protein Source E.Coli Species Human

Recombinant Human CD163 - CD163-27220TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human CD163, GST-tagged - CD163-10910H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human CD163, His-tagged - CD163-112H from Creative Biomart Category Protein Source NSO Cells Species Human

Recombinant Human CD163, His-tagged - CD163-510H from Creative Biomart Category Protein Source NSO cells Species Human

CD163 Human - NKX-482 from Reagent Proteins Category Protein Prices $348.00, $2,047.00 Sizes 50.00 µg, 1 mg Source E.coli Species Human

Recombinant Cluster Of Differentiation (CD163) - RPB726Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Cluster Of Differentiation (CD163) - RPB726Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Cluster Of Differentiation (CD163) - RPB726Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Cluster Of Differentiation (CD163) - RPB726Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Human Scavenger receptor cysteine-rich type 1 protein M130(CD163) ,partial - CSB-YP801238HU CSB-EP801238HU CSB-BP801238HU CSB-MP801238HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human CD163 Protein, CF - 1607-CD from R&D Systems Category Protein Prices $339.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Gly41-Ser1045, with a C-terminal 10-His tag Species Human

Human CD163 Protein - CD3-H52E8 from ACROBiosystems Category Protein Prices $350.00, $2,200.00 Sizes 100 µg, 1 mg (500ug x 2) Source Human CD163 Protein (Human CD163, His Tag) Ser 42 - Ser 1045 (Accession # Q86VB7) was produced in human 293 cells (HEK293) at ACROBiosystems. Species Human

CD163 Protein - abx163597 from Abbexa Category Protein Species Mouse

CD163 (transcript variant 1) - TP308557 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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