| Gene Symbol |
CD163
|
| Entrez Gene |
9332
|
| Alt Symbol |
M130, MM130
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CD163 molecule
|
| Other Description |
hemoglobin scavenger receptor|macrophage-associated antigen|scavenger receptor cysteine-rich type 1 protein M130
|
| Swissprots |
Q07900 Q07898 Q07899 Q07901 Q86VB7 Q2VLH7 C9JIG2
|
| Accessions |
CAB45233 EAW88662 EAW88663 EAW88664 EAW88665 EAW88666 Q86VB7 AA962842 AI128043 AI129762 AK226017 BC051281 AAH51281 DA619387 DB291765 DQ058615 AAY99762 Z22968 CAA80541 Z22969 CAA80542 Z22970 CAA80543 Z22971 CAA80544 XM_005253528 XP_005253585 XM_005253529 XP_005253586 NM_004244 NP_004235 NM_203416 NP_981961
|
| Function |
Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
|
| Subcellular Location |
Soluble CD163: Secreted.
|
| Tissue Specificity |
Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood. {ECO:0000269|PubMed:10577520, ECO:0000269|PubMed:11196644, ECO:0000269|PubMed:16434690}.
|