| Gene Symbol |
OSGEP
|
| Entrez Gene |
55644
|
| Alt Symbol |
GCPL1, KAE1, OSGEP1, PRSMG1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
O-sialoglycoprotein endopeptidase
|
| Other Description |
N6-L-threonylcarbamoyladenine synthase|hOSGEP|probable O-sialoglycoprotein endopeptidase|probable tRNA N6-adenosine threonylcarbamoyltransferase|probable tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP|t(6)A synthase|t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP|tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP
|
| Swissprots |
Q6IAC3 Q9NPF4
|
| Accessions |
BAB33147 EAW66469 EAW66470 Q9NPF4 AB050442 BAB33172 AF052137 AJ271669 CAB71031 AK000418 BAA91150 AK054823 AK055492 BC032310 AAH32310 BX428958 CD365329 CR457232 CAG33513 DA068526 DQ894806 ABM85732 EU176277 ABW03728 XM_011536930 XP_011535232 XM_011536931 XP_011535233 XM_011536932 XP_011535234 NM_017807 NP_060277
|
| Function |
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. {ECO:0000255|HAMAP-Rule:MF_03180}.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03180}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03180, ECO:0000269|PubMed:22912744}.
|
| Tissue Specificity |
Widely expressed at low level. Expressed in heart, placenta, liver, kidney, lung, brain, skeletal muscle and pancreas. {ECO:0000269|PubMed:12039036}.
|
![Western Blot: OSGEP Overexpression Lysate (Adult Normal) [NBL1-13999] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for OSGEP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/19412_OSGEP%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-13999-img0002.jpg)