Gene Symbol | OSGEP |
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Entrez Gene | 55644 |
Alt Symbol | GCPL1, KAE1, OSGEP1, PRSMG1 |
Species | Human |
Gene Type | protein-coding |
Description | O-sialoglycoprotein endopeptidase |
Other Description | N6-L-threonylcarbamoyladenine synthase|hOSGEP|probable O-sialoglycoprotein endopeptidase|probable tRNA N6-adenosine threonylcarbamoyltransferase|probable tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP|t(6)A synthase|t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP|tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP |
Swissprots | Q6IAC3 Q9NPF4 |
Accessions | BAB33147 EAW66469 EAW66470 Q9NPF4 AB050442 BAB33172 AF052137 AJ271669 CAB71031 AK000418 BAA91150 AK054823 AK055492 BC032310 AAH32310 BX428958 CD365329 CR457232 CAG33513 DA068526 DQ894806 ABM85732 EU176277 ABW03728 XM_011536930 XP_011535232 XM_011536931 XP_011535233 XM_011536932 XP_011535234 NM_017807 NP_060277 |
Function | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. {ECO:0000255|HAMAP-Rule:MF_03180}. |
Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03180}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03180, ECO:0000269|PubMed:22912744}. |
Tissue Specificity | Widely expressed at low level. Expressed in heart, placenta, liver, kidney, lung, brain, skeletal muscle and pancreas. {ECO:0000269|PubMed:12039036}. |
Human OSGEP full length protein - ab132776 from Abcam
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Human OSGEP full length protein - ab183238 from Abcam
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Human OSGEP protein fragment - ab127148 from Abcam
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OSGEP Antibody Blocking Peptide - LS-E20794 from LifeSpan Bioscience
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OSGEP Antibody Blocking Peptide - LS-E20793 from LifeSpan Bioscience
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OSGEP Recombinant Protein - H00055644-P01 from Novus Biologicals
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OSGEP Blocking Peptide - 33R-7254 from Fitzgerald
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OSGEP Blocking Peptide - 33R-2460 from Fitzgerald
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OSGEP protein (His tag) - 80R-3926 from Fitzgerald
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OSGEP / GCPL1 (His-tag) - AR51613PU-N from Acris Antibodies
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OSGEP / GCPL1 (His-tag) - AR51613PU-S from Acris Antibodies
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OSGEP / GCPL1 - H00055644-P01-10 from Acris Antibodies
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OSGEP / GCPL1 - H00055644-P01-25 from Acris Antibodies
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OSGEP fusion protein - ag4308 from Proteintech Group
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Recombinant Human Probable tRNA threonylcarbamoyladenosine biosynthesis protein - CSB-YP878842HU CSB-EP878842HU CSB-BP878842HU CSB-MP878842HU from Cusabio
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OSGEP, 1- 335aa, Human, His tag, E.coli (Denatured) - ATGP2793 from ATGen
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OSGEP Protein - abx164377 from Abbexa
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OSGEP / GCPL1 - TP307089 from Acris Antibodies
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Probable tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP (OSGEP), Recombinant Protein - MBS1376928 from MyBioSource
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OSGEP Recombinant Protein Antigen - NBP1-83378PEP from Novus Biologicals
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OSGEP-Antibody-C-term-Blocking-peptide - BP5329b from Abgent, a WuXi AppTec company
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OSGEP Peptide, Human - M34GP11143H from Creative Peptides
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Recombinant Human OSGEP Protein - NBP2-51805 from Novus Biologicals
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O-Sialoglycoprotein Endopeptidase, Human Recombinant - 228-20766-1 from RayBiotech
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