APBB1IP

Gene Symbol	APBB1IP
Entrez Gene	54518
Alt Symbol	INAG1, PREL1, RARP1, RIAM
Species	Human
Gene Type	protein-coding
Description	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
Other Description	APBB1-interacting protein 1|PREL-1|RARP-1|Rap1-GTP-interacting adaptor molecule|Rap1-interacting adaptor molecule|amyloid beta A4 precursor protein-binding family B member 1-interacting protein|proline rich EVH1 ligand 1|proline-rich EVH1 ligand 1|proline-rich protein 73|rap1-GTP-interacting adapter molecule|retinoic acid-responsive proline-rich protein 1
Swissprots	Q8IYL7 Q8IZZ7 Q8IWS8 Q7Z5R6
Accessions	CCQ43613 EAW86095 EAW86096 EAW86097 EAW86098 EAW86099 Q7Z5R6 AB085852 BAC41256 AK000812 BAA91384 AK303597 BAG64612 AK308916 AY152730 AAN75525 BC035636 AAH35636 BC054516 AAH54516 BM150270 BM556115 XM_006717451 XP_006717514 XM_011519514 XP_011517816 NM_019043 NP_061916
Function	Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin- induced promoter activities through AP1 and SRE. Mediates Rap1- induced adhesion. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}.
Subcellular Location	Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F- actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity). {ECO:0000250}.
Tissue Specificity	Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}.
Top Pathways	Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human APBB1IP Gene cDNA Clone - orb141829 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-APBB1IP-cDNA-Clone - DC06913 from Abgent, a WuXi AppTec company Prices $232.20 Sizes 10 µg Species Human Accession BC035636

APBB1IP - MBS1269709 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC035636

Human APBB1IP cDNA clone(NM_019043.3) - CDFG002216 from Creative Biomart Species Human Accession NM_019043.3

Human APBB1IP ORF Clone(NM_019043.3) - CDCR304477 from Creative Biomart Species Human Accession NM_019043.3

Human APBB1IP ORF Clone(NM_019043.3) - CDCR304478 from Creative Biomart Species Human Accession NM_019043.3

Human APBB1IP ORF Clone(NM_019043.3) - CDCL154058 from Creative Biomart Species Human Accession NM_019043.3

Human APBB1IP/RIAM Gene ORF cDNA clone in cloning vector - HG12234-G from Sino Biological Species Human

Human APBB1IP/RIAM Gene ORF cDNA clone expression plasmid, N-Flag tag - HG12234-NF from Sino Biological Species Human

Human APBB1IP/RIAM Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG12234-ACG from Sino Biological Species Human

Human APBB1IP/RIAM Gene ORF cDNA clone expression plasmid, N-Myc tag - HG12234-NM from Sino Biological Species Human

Human APBB1IP/RIAM Gene ORF cDNA clone expression plasmid, C-Flag tag - HG12234-CF from Sino Biological Species Human

Human APBB1IP/RIAM Gene ORF cDNA clone expression plasmid, C-Myc tag - HG12234-CM from Sino Biological Species Human

Human APBB1IP/RIAM Gene ORF cDNA clone expression plasmid, C-HA tag - HG12234-CY from Sino Biological Species Human

Human APBB1IP/RIAM Gene ORF cDNA clone expression plasmid, N-His tag - HG12234-NH from Sino Biological Species Human

Human APBB1IP/RIAM Gene ORF cDNA clone expression plasmid, N-HA tag - HG12234-NY from Sino Biological Species Human

Human APBB1IP/RIAM Gene ORF cDNA clone expression plasmid - HG12234-UT from Sino Biological Species Human

Human APBB1IP/RIAM Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG12234-ACR from Sino Biological Species Human

Human APBB1IP/RIAM Gene ORF cDNA clone expression plasmid, C-His tag - HG12234-CH from Sino Biological Species Human

Human APBB1IP ORF clone (NM_019043.3) - CDCR028678 from Creative biogene Species Human

Human APBB1IP ORF Clone (BC035636) - CDCS414929 from Creative biogene Species Human Accession Q7Z5R6

Human APBB1IP ORF clone (BC035636) - CDCB160185 from Creative biogene Species Human

Human APBB1IP cDNA Clone(NM_019043.3) - CDFG002216 from Creative biogene Species Human

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