APBB1IP

Gene Symbol APBB1IP
Entrez Gene 54518
Alt Symbol INAG1, PREL1, RARP1, RIAM
Species Human
Gene Type protein-coding
Description amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
Other Description APBB1-interacting protein 1|PREL-1|RARP-1|Rap1-GTP-interacting adaptor molecule|Rap1-interacting adaptor molecule|amyloid beta A4 precursor protein-binding family B member 1-interacting protein|proline rich EVH1 ligand 1|proline-rich EVH1 ligand 1|proline-rich protein 73|rap1-GTP-interacting adapter molecule|retinoic acid-responsive proline-rich protein 1
Swissprots Q8IYL7 Q8IZZ7 Q8IWS8 Q7Z5R6
Accessions CCQ43613 EAW86095 EAW86096 EAW86097 EAW86098 EAW86099 Q7Z5R6 AB085852 BAC41256 AK000812 BAA91384 AK303597 BAG64612 AK308916 AY152730 AAN75525 BC035636 AAH35636 BC054516 AAH54516 BM150270 BM556115 XM_006717451 XP_006717514 XM_011519514 XP_011517816 NM_019043 NP_061916
Function Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin- induced promoter activities through AP1 and SRE. Mediates Rap1- induced adhesion. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}.
Subcellular Location Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F- actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity). {ECO:0000250}.
Tissue Specificity Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}.
Top Pathways Rap1 signaling pathway

APBB1IP CRISPR/Cas9 KO Plasmid (h) - sc-412298 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

APBB1IP HDR Plasmid (h) - sc-412298-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APBB1IP Double Nickase Plasmid (h) - sc-412298-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APBB1IP Double Nickase Plasmid (h2) - sc-412298-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APBB1IP CRISPR Activation Plasmid (h) - sc-412298-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

APBB1IP CRISPR Activation Plasmid (h2) - sc-412298-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

APBB1IP Lentiviral Activation Particles (h) - sc-412298-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APBB1IP Lentiviral Activation Particles (h2) - sc-412298-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APBB1IP siRNA (h) - sc-90400 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

APBB1IP shRNA Plasmid (h) - sc-90400-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

APBB1IP shRNA (h) Lentiviral Particles - sc-90400-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU081251 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3308 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3308 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

APBB1IP siRNA (Human) - CRJ0110 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

APBB1IP - MBS8207877 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human APBB1IP (NM_019043.3) - SHH238066 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human APBB1IP(NM_019043.3) - SHG032677 from Creative biogene

Category siRNA
Species Reactivities Human

APBB1IP shRNA Plasmid (Human) - CHJ0110 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

APBB1IP miRNA 3'UTR clone - MiUTR1H-00456 from Creative biogene

Species Reactivities Human
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